Spedra 100mg (Avanafil): Reviews, Dosage, Side Effects and How to Buy Online

Spedra 100mg is a prescription only tablet containing avanafil, licensed in the UK for the treatment of erectile dysfunction in adult men. It received European marketing authorisation in June 2013 and launched in the UK in March 2014, which makes it the newest of the four tablets NICE names as first line treatment.

Two things shape what this page can and cannot do.

This page contains no customer reviews or ratings. Avanafil is a prescription medication, and publishing user testimonials for one is not something a registered pharmacy should do. What replaces reviews here is the trial evidence, with participant numbers attached, so you can judge the medicine on data rather than on anonymous opinion.

This page gives no dosing instructions. Strength and how to take it are decided by a prescriber after assessment, not chosen at checkout. What you will find instead is what the licensed strengths are, what the evidence shows for each, and the safety guardrails that apply whatever you are prescribed.

Spedra tablets belong to the medication group known as PDE5 inhibitors, which work by relaxing blood vessels to increase blood flow. This mechanism helps improve erectile function when a man is stimulated. Drinking alcohol at the same time as Spedra can increase the risk of low blood pressure, dizziness and other side effects, and may also make it harder to achieve an erection.

Spedra is not suitable for everyone. It must not be taken with nitrates or nitric oxide donors, and it is contraindicated in certain cardiovascular, kidney, liver and retinal conditions. People with conditions that may increase the risk of prolonged erections, such as sickle cell disease, multiple myeloma, leukaemia or certain penile conditions including Peyronie's disease, should discuss this with a clinician before treatment. People with bleeding disorders or active peptic ulceration also need an individual benefit-risk assessment.

Spedra works best when taken at the recommended dose approximately 15 to 30 minutes before sexual activity. Avoid grapefruit juice for at least 24 hours before taking Spedra, as it can interfere with how the chemical is excreted and increase side effects.

Seek urgent medical attention for an erection lasting four hours or more, sudden loss of vision or hearing, or other severe or unexpected symptoms such as chest pain.

Online doctor services provide a discreet service where you can submit delivery requests for Spedra with express delivery and discreet packaging, ensuring privacy. This private prescription service allows treatment delivered directly to your door with excellent service and discreet delivery options.

Always inform your prescriber about other medications or herbal remedies you are taking, as some can interact with Spedra. For example, Spedra must not be used with nitrates or other erectile dysfunction treatments due to risk of dangerously lowering blood pressure.

If you have a history of heart attack, serious liver disease, or abnormal prostate test results, your doctor will assess whether Spedra is the right treatment for you. Tell your prescriber about any history of heart disease, liver or kidney problems, or other relevant medical conditions so they can assess whether avanafil is suitable

Store Spedra tablets in a cool, dry place away from direct sunlight and out of reach of children. Never take more Spedra than prescribed. The maximum recommended dosing frequency is once a day.

If you experience indigestion, headache, facial flushing, or nasal congestion, these are common side effects and usually subside as the medication wears off. However, if you notice any unusual symptoms or serious side effects, contact your healthcare provider promptly.

This medication is licensed for the treatment of erectile dysfunction in adult men. If you have any concerns about treatment delivered or your response, consult your prescriber rather than seeking more Spedra independently.

For safe and legal purchase, always order Spedra through a registered UK pharmacy with a valid private prescription. Using a registered pharmacy and a properly prescribed medicine helps ensure that the product comes through a regulated supply chain.

Remember, herbal remedies are not a substitute for prescription medication and should be discussed with your doctor before use alongside Spedra.

This page aims to provide comprehensive information about Spedra 100mg, including treatment options, safety precautions, and how to access online doctor services for a discreet and convenient experience.

Key things to know

• Spedra contains avanafil and is licensed for the treatment of erectile dysfunction in adult men.
• It comes in three strengths: 50mg, 100mg and 200mg. Your prescriber determines which is appropriate.
• The NICE evidence summary states the approved timing is approximately 30 minutes beforehand.
• NICE states plainly that "it is not known how avanafil compares to other PDE5 inhibitors", because no head to head trials exist.
• The most common side effects are headache, flushing, and nasal and sinus congestion, each with an incidence between 1 in 10 and 1 in 100.
• It is contraindicated with nitrates. That is an absolute limit, not a caution.
• Standard price at this pharmacy starts at £24.29 for 4 tablets of 100mg strength.

What is Spedra 100mg?

Spedra 100mg UK supply is a tablet containing 100mg of avanafil, a PDE5 inhibitor. The NICE evidence summary describes its licensed indication as the "treatment of erectile dysfunction in adult men".

PDE5 inhibitors slow an enzyme that ends an erection. They do not create the signal that starts one, but allow the body's own chemical signal to go further, increasing the blood flow available. They require sexual stimulation and an intact enough physiological pathway for an erection to occur, so response can vary depending on the underlying cause of ED.

The NICE evidence summary names four medicines in this group as first line drug treatment for erectile dysfunction: avanafil, sildenafil, tadalafil and vardenafil. Avanafil is the most recently licensed of the four.

Spedra avanafil 100mg: what is actually in it

The active ingredient is avanafil. The 100mg tablet contains 100mg of it, which is the middle of the three licensed strengths.

Avanafil is a prescription only medicine in the UK. It cannot be sold over the counter, and any website offering it without a clinical assessment is not operating lawfully. There is a section on that further down.

Spedra 100mg tablets: the strengths available

Three strengths are licensed, and NICE lists all three.

Strength is a clinical decision. Your prescriber will determine the appropriate treatment and strength based on your medical history, your other medicines and your cardiovascular health. It is not something to select yourself, and a higher number is not a better outcome.

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Spedra 100mg reviews: why you will not find them here

There are no reviews, ratings, star scores or forum quotes on this page, and that is deliberate rather than an omission.

Avanafil is a prescription only medicine. Presenting user testimonials or aggregated ratings for one encourages people to choose a prescription treatment on the basis of other people's experiences rather than a clinical assessment, and means publishing claims nobody has verified.

There is a second problem with review-led decisions on this specific medicine, and it is the most useful thing on this page. Response to a PDE5 inhibitor depends heavily on why you have erectile dysfunction, not on the medicine's general quality. The same avanafil trials that reported one response rate in a general population reported roughly half that rate in men after prostate surgery.

So what follows is trial data with the population and participant numbers attached, which is what a review score is a poor substitute for.

What the trial evidence shows instead

The NICE evidence summary describes three 12 week randomised controlled trials of avanafil, plus a longer extension study.

On the main effectiveness endpoint in the general population, response was 57.1% for avanafil 100mg against 27.0% for placebo. Among the 298 men after prostate surgery, the same medicine at the same strength gave 23.4% against 8.9%.

That gap is the most important thing to understand before buying. Nothing about the medicine changed between those groups. The difference illustrates how responses can vary substantially between patient populations and underlying causes.

Spedra 100mg vs 200mg: what the trials found

The trials measured both strengths, and the difference between them is smaller than the difference between populations.

Using the erectile function score improvement reported by NICE for the general population trial, avanafil 100mg produced an improvement of 8.3 points and 200mg produced 9.4 points, against 2.9 points on placebo. In the diabetes trial the figures were 4.6 points for 100mg and 5.3 points for 200mg, against 1.8 points on placebo.

Both strengths substantially outperformed placebo in both populations. The gap between 100mg and 200mg was around one point in each trial, while the gap between the two populations was several points at the same strength.

This is not a reason to ask for a higher strength. Your prescriber decides strength based on your assessment, and side effect frequency is part of that judgment. Treatment suitability depends on an individual clinical assessment.

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Is Spedra 100mg effective?

The trial evidence shows meaningful improvement against placebo across three separate populations, and the size of that improvement depends on the underlying cause.

The clearest view is the erectile function score data above: 8.3 points of improvement at 100mg against 2.9 on placebo in a general population, and 4.6 against 1.8 in men with diabetes. Both are real differences, and neither is a promise for any individual. Two honest limits belong here.

Trial averages hide the range. A response rate of 57.1% means a majority of participants met a defined endpoint and a substantial minority did not. Results vary between individuals.

The evidence does not show it is better than the alternatives. That is covered in its own section below, because it is the question most people actually have.

Spedra 100mg how long does it work?

The NICE evidence summary states that the currently approved timing is to take it approximately 30 minutes beforehand.

That 30 minute figure is the licensed timing rather than a maximum. NICE also records that at the time of its review, a submission to shorten the approved timing to approximately 15 minutes after dosing was pending with the European regulator.

What NICE does not publish is a duration figure for avanafil, so this page does not give one. Inventing a number for how many hours it lasts would be exactly the sort of unverified claim that fills competing pages.

If timing is your main concern, that is a legitimate thing to raise at the consultation. The four first line medicines differ in how they are taken and how long they act, and one comes in a daily form that removes timing from the question entirely. Your prescriber will determine the appropriate treatment.

Spedra 100mg dosage and how to take it

The appropriate dose depends on your clinical assessment. A website should not encourage you to change or increase your dose without advice from your prescriber.

What can be said is what the licence covers. Three strengths are licensed, and the approved timing is approximately 30 minutes beforehand. Everything else, including which strength suits you and how often it can be taken, comes from the prescriber and from the patient information leaflet supplied with your medicine. Read that leaflet: it is specific to the product you receive and is the authoritative document for your treatment.

Missed dose and never doubling up

Two safety guardrails apply to this whole group of medicines.

Never take more than the prescribed amount in a day. Taking extra does not improve the outcome and does increase the risk of side effects.

Never double up to make up for an occasion that did not work. An occasion that falls short is information for your prescriber, not a reason to take another tablet.

If treatment has been taken as directed and is not producing the result you expected, go back to the prescriber, who can review whether the cause has been identified and treated, whether another medicine is contributing, and whether a different option is appropriate.

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Spedra 100mg side effects

The NICE evidence summary lists the most common adverse events with their frequency bands, which is more useful than a general warning.

These effects are classed as common, but most people taking the medicine will not experience each of them. This is not the complete list. The patient information leaflet supplied with your medicine contains the full set, including rare effects, and should be read before you take anything.

Report side effects. Suspected side effects from any medicine can be reported to the MHRA through the Yellow Card scheme, which is how safety signals are identified after a medicine reaches the market.

Who cannot take Spedra

Some people cannot take avanafil at all, and this is not a list of cautions to weigh up.

The NICE evidence summary names the contraindications, and nitrates come first. The current SmPC includes:

• Nitrates/nitric oxide donors
• Recent MI/stroke/life-threatening arrhythmia within 6 months
• Resting hypotension
• Uncontrolled hypertension
• Unstable angina/angina with intercourse
• Certain heart failure
• Severe hepatic impairment
• Severe renal impairment
• Certain retinal conditions
• Potent CYP3A4 inhibitors
• Riociguat

Alongside those, anyone taking an alpha blocker should raise it before starting any medicine in this group. And if you become very breathless or get chest pain on light or moderate activity, the priority is a cardiovascular assessment rather than a prescription.

Never stop a prescribed heart medicine in order to take a treatment for erectile dysfunction.

Spedra 100mg compared with other tablets: what the evidence says

There are no head to head trials, and NICE says so directly. This is the most useful and least published fact about avanafil.

The NICE evidence summary states that "no data are available from double- or triple-blind multicentre studies comparing the efficacy of" the medicines in this group, and concludes that "it is not known how avanafil compares to other PDE5 inhibitors".

That single quotation answers the comparison question more honestly than any comparison table could. Anyone ranking these medicines is comparing figures from separate trials in different populations, never designed to be compared.

What genuinely differs between the four first line medicines is not proven potency. It is:

• How they are taken, including the approved timing before use
• How long they act, which varies considerably across the group
• Whether a daily option exists, which only one of the four offers
• Whether a generic version exists, which affects cost rather than clinical content
• How each one suits you individually, which is what the assessment is for

No medicine in this group can be described as better than the others as a general statement. Your prescriber will determine the appropriate treatment after reviewing your medical history, current medicines and cardiovascular health.

Spedra 100mg price and pack sizes

Standard prices at this pharmacy are below, with cost per tablet worked out so the pack sizes can be compared directly.

Three things worth understanding about that table.

Cost per tablet is not a measure of effectiveness. A medicine that suits you at a higher cost is a better outcome than one that does not at a lower cost.

Larger is not automatically cheaper per tablet here. The 16 tablet pack works out at a lower cost per tablet than the 24 and 32 tablet packs. If you are comparing pack sizes on cost, check the arithmetic rather than assuming the biggest pack is the most economical.

Avanafil is available in the UK as a branded tablet. Where a medicine has a generic version, that is usually the lower cost route to the same active ingredient, and it is a reasonable thing to raise at the consultation.

Prices are standard website prices at the time of writing and are subject to change. Strength and quantity are determined following clinical assessment, not selected freely at checkout.

How to buy Spedra 100mg online in the UK

Through a registered pharmacy, after an assessment. There is no lawful route to buy Spedra online in the UK without one, because avanafil is a prescription only medicine.

The process runs in four steps:

• Complete an online consultation. A clinical questionnaire covering your symptoms, medical history, current medicines and cardiovascular health.
• Prescriber review. An online consultation with UK registered prescribers, who determine whether treatment is appropriate and which treatment and strength are appropriate.
• Supply from a registered pharmacy. EverydayMeds is a GPhC registered pharmacy, and clinical assessment happens before supply.
• Review if it does not suit. A treatment that does not work as expected is a reason to go back to the prescriber, not a reason to buy more or buy elsewhere.

To find out whether treatment is appropriate for you, you can check your eligibility for erectile dysfunction treatment through an online consultation with UK registered prescribers.

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How to check a pharmacy is genuine

This matters more than price, and it takes about a minute.

• Check that the pharmacy is appropriately registered and that the medicine is authorised for supply in the UK.
• A clinical assessment is required before supply. Any site selling a prescription only medicine without one is not operating lawfully.
• Check the medicine is UK sourced and licensed, rather than described vaguely as an equivalent.
• Be cautious of unusually low prices, particularly when the seller's pharmacy or regulatory status cannot be verified.

The MHRA reported in February 2026 that it had seized around 19.5 million doses of illegal erectile dysfunction pills between 2021 and 2025, stating that such products "may contain no active ingredient, the wrong dose, hidden drugs or toxic ingredients", and that unlicensed products can be especially dangerous for people with heart disease or high blood pressure.

Red flags: when to seek advice rather than order

Seek advice promptly if any of the following apply:

• Chest pain, breathlessness or palpitations, especially on exertion.
• You cannot walk briskly for 20 minutes or climb two flights of stairs without becoming breathless.
• Pain in the calves or thighs when walking that eases with rest.
• You take a nitrate or a nitric oxide donor.
• An erection lasting more than four hours, known as priapism, which needs urgent medical attention.
• Sudden vision loss or sudden hearing loss after taking any medicine in this group.
• Pain when you get an erection, or a lump or change in shape or curvature.
• A change in erectile function within weeks of starting a new medicine.

Erectile dysfunction can be an early sign of a wider circulation problem. The NICE evidence summary notes it may be an early manifestation of coronary artery and peripheral vascular disease, which is why the cardiovascular items sit at the top of that list.

Medical Disclaimer

This article is general information and does not replace personalised medical advice. It gives no dosing instructions and should not be used to self diagnose, self prescribe, self medicate, or to start, stop or change any medicine.

Avanafil is a prescription only medicine. Suitability for any treatment depends on an individual clinical assessment by an appropriately qualified prescriber, who will consider your medical history, current medicines and cardiovascular health. This medicine should only be used under the supervision of an appropriately qualified prescriber. Results vary between individuals.

The trial figures on this page describe averages across defined study populations and are not predictions for any individual. The side effect information here is not a complete list. Read the patient information leaflet supplied with your medicine before taking it.

Never take more than the prescribed amount of any medicine, and never take an extra tablet to make up for one that did not appear to work.

If you experience chest pain, an erection lasting more than four hours, sudden vision loss or sudden hearing loss, seek urgent medical attention.