Can Mounjaro Decrease Libido? What the Evidence Says (October 2026)

01 · Core answer

Is Mounjaro the reason your libido has dropped?

Possibly not, and the evidence does not show that it is. Reduced libido is not a listed side effect in the SmPC or the patient information leaflet.¹¹³ That is different from saying nobody ever feels a change. Desire is shaped by many things at once, and a medicine that changes how you eat can sit in the middle of several of them.

If you want the wider picture, our guides on Mounjaro and libido and whether Mounjaro affects libido cover the related questions.

02 · Next step

What to do if you notice a change

Start by noting when it began and what else changed around the same time.

If you are already a customer, raise it at your review with our prescribing team. If you are still deciding on treatment, our weight loss clinic explains how a consultation works.

03 · How Mounjaro could matter indirectly

How Mounjaro could matter indirectly

Mounjaro works on gut-hormone receptors to help regulate appetite and slow how quickly the stomach empties. Most people feel fuller sooner and less hungry between meals.¹ That is the intended effect.

Where people feel different, the more plausible routes are indirect: eating well below usual intake, feeling tired or queasy in the early weeks, or the emotional adjustment of a changing body. These are reasonable possibilities to discuss, not proven causes. Our page on how quickly Mounjaro reduces appetite explains the usual pattern of early changes.

04 · Women and libido

Does Mounjaro decrease libido in women?

There is no separate listed libido effect for women either. The product information does not single out desire in either sex.¹ Women do face more hormone-related reasons for a change, such as perimenopause, menopause, pregnancy, breastfeeding or hormonal contraception, none of which are caused by Mounjaro. Mounjaro must not be used during pregnancy, and it should be stopped at least one month before trying to conceive. If you become pregnant during treatment, stop the medicine and tell your prescriber promptly.

One practical point: Mounjaro slows stomach emptying, which can reduce how well oral contraceptive pills are absorbed.⁷ The SmPC advises switching to a non-oral method, or adding a barrier method (such as condoms), for 4 weeks after starting Mounjaro and for 4 weeks after each dose increase.¹ Never stop a contraceptive on your own because of a libido question.

05 · Reporting and reviewing

Reporting a new symptom

If a symptom is new since you started, tell your prescriber and consider reporting it through the MHRA Yellow Card scheme.¹⁹ Reporting does not mean the medicine caused the symptom.

Our aftercare includes ongoing monthly reviews and side-effect support from the prescribing team, so you do not have to manage it alone. Do not change or stop your dose without speaking to a prescriber first. If your concern is about whether the treatment is right for you, our guides on whether it can impact libido and whether it can kill libido take the same evidence-led approach.

06 · Weight loss and desire

Could losing weight itself change desire?

For some people, weight loss brings the opposite change, with more confidence and energy. Our page on whether Mounjaro might increase libido looks at that side.

Treatment works alongside a reduced-calorie diet and increased physical activity. Eating enough protein and food overall, sleeping well and keeping active are sensible habits whatever your libido is doing. If you are comparing appetite approaches generally, see how to decrease appetite.

07 · Serious side effects

Serious side effects: when to get help straight away

Serious side effects are uncommon but need urgent attention. Seek immediate medical help for: severe, persistent stomach pain that may spread to your back, with or without vomiting (possible pancreatitis); pain in the upper right abdomen, fever or yellowing of skin/eyes (possible gallbladder problems); or signs of a severe allergic reaction such as swelling of the face or throat and difficulty breathing. If you take insulin or a sulfonylurea alongside Mounjaro, watch for low blood sugar (shakiness, sweating, confusion) — your prescriber may need to adjust those medicines.¹ There is no proven way to prevent pancreatitis or gallbladder problems while taking Mounjaro, so learn these warning signs and get medical help straight away if they appear.