Orlistat vs Xenical: Which Should You Choose?
How Both Orlistat and Xenical Work (Not Appetite Suppressants)
Both Orlistat 120mg and Xenical 120mg work identically in your digestive system by blocking lipase enzymes that break down dietary fat. Approximately one third of the fat you eat passes through unabsorbed. Neither product suppresses appetite or acts on the brain - they work locally in the gut to reduce fat absorption. This mechanism supports weight management when combined with a reduced-calorie, lower-fat diet and increased physical activity.
The Key Difference: Price Comparison
Generic Orlistat 120mg offers substantial savings versus branded Xenical 120mg. A 4-week supply (84 capsules) costs £29.69 for Orlistat versus £38.69 for Xenical (with EDM10 discount) - saving you £9 per month. Over 12 weeks, choose Orlistat at £86.39 or Xenical at £116.09, saving £29.70 with the generic option. Both deliver identical clinical results as they contain the same active ingredient at the same strength.
Which Option Should You Buy?
Choose generic Orlistat 120mg if you want maximum value and identical clinical effects. The active ingredient, dosing (one capsule three times daily with meals), and fat-blocking mechanism are identical to Xenical. Choose branded Xenical 120mg if you prefer the original Roche-manufactured version and don't mind paying extra for the brand name. Both require prescription following clinical assessment and work best when dietary fat is kept low (approximately 15g per meal).
Alli 60mg: Lower-Strength Alternative
Alli 60mg contains half the orlistat dose of prescription-strength options. At £26.09 for 4 weeks (with EDM10), it provides a gentler introduction with typically milder gastrointestinal side effects. However, it blocks a smaller proportion of dietary fat compared to the 120mg prescription versions.
Your Prescription Options at EverydayMeds
Following online clinical assessment by UK-licensed prescribers, you can access: Orlistat 120mg from £15.20 (2-week supply) to £86.39 (12-week supply), Xenical 120mg from £19.35 to £116.09, or Alli 60mg from £26.09 to £116.99. All prices include 10% discount with code EDM10. Your prescriber will determine suitability based on your BMI, health circumstances, and weight management goals.
Order Today with Next Day Delivery
Complete your online health questionnaire for prescriber review. If clinically appropriate, your chosen treatment will be dispensed by our GPhC-registered pharmacy and delivered discreetly to your address. Start saving with generic Orlistat or choose branded Xenical - both support your weight management journey effectively.


