Which Should You Buy: Orlistat or Xenical?
Orlistat vs Xenical: The Key Facts
Both Orlistat 120mg and Xenical 120mg contain the same active ingredient at identical doses, making them clinically equivalent. The primary difference is cost - generic Orlistat offers substantial savings over branded Xenical whilst delivering the same fat-blocking effect. Both work by inhibiting lipase enzymes to block approximately one third of dietary fat absorption when used alongside a reduced-calorie, lower-fat diet.
Price Comparison: Orlistat vs Xenical
Generic Orlistat 120mg costs £32.99 for 4 weeks (£29.69 with EDM10), whilst branded Xenical costs £42.99 for 4 weeks (£38.69 with EDM10). This represents monthly savings of approximately £9 choosing generic over branded. For 12-week supplies, Orlistat costs £95.99 (£86.39 with EDM10) compared to Xenical at £128.99 (£116.09 with EDM10) - saving nearly £30 over three months.
Clinical Effectiveness: Identical Results
Both formulations contain 120mg orlistat per capsule and work through the same mechanism. They block approximately one third of dietary fat from being absorbed, supporting weight management when combined with appropriate diet and exercise. Individual responses vary, but the clinical effect remains identical between generic and branded versions. Both require the same dosing schedule of one capsule with each main meal containing fat.
Alli 60mg: Lower-Strength Alternative
Alli provides half the dose at 60mg per capsule, offering a gentler introduction to orlistat treatment. Priced at £28.99 for 4 weeks (£26.09 with EDM10), Alli may suit those preferring lower-strength treatment or experiencing side effects with 120mg doses. However, the reduced dose means less fat-blocking capability compared to prescription-strength options.
Online Prescription Process
Both Orlistat and Xenical require prescription following clinical assessment by UK-licensed prescribers. Complete our online health questionnaire covering medical history, current medications, and BMI information. Treatment suitability is assessed individually, with prescriptions issued where clinically appropriate. Our GPhC-registered pharmacy dispenses and dispatches with next day delivery across the UK.
Managing Side Effects
Both formulations may cause gastrointestinal side effects including oily stools, increased bowel movements, and abdominal discomfort. These effects occur more frequently with high-fat meals and can be minimised by keeping dietary fat intake to approximately 15g per meal. Side effects typically reduce as dietary habits adapt. Both products have identical side effect profiles due to containing the same active ingredient.
Making Your Choice
Choose generic Orlistat 120mg for maximum cost savings whilst maintaining clinical effectiveness. Select branded Xenical if you prefer established branding. Consider Alli 60mg for lower-strength treatment. All three options are available following online consultation with 10% discount using code EDM10 and next day delivery from our Leicester-based GPhC-registered pharmacy.


