Which Prescription Weight Loss Treatment Is Right for You?
How Xenical and Mysimba Work Differently
Xenical (orlistat 120mg) and Mysimba represent two distinct approaches to prescription weight loss treatment in the UK. Xenical works locally in the gut by blocking approximately one third of dietary fat absorption. The unabsorbed fat passes naturally through your system. Mysimba, conversely, contains naltrexone and bupropion which may affect appetite and food cravings through brain pathways.
Both treatments require clinical assessment and must be used alongside a reduced-calorie diet and increased physical activity. Your prescriber will determine which option may be most suitable based on your individual health circumstances and medical history.
Xenical vs Generic Orlistat - Same Active Ingredient
Before comparing with Mysimba, it's worth noting that Xenical and generic orlistat contain identical active ingredients at the same 120mg dose. Generic orlistat offers significant cost savings - a 4-week supply costs £32.99 (£29.69 with EDM10) compared to Xenical at £42.99 (£38.69 with EDM10). Both are clinically equivalent and work identically to block approximately one third of dietary fat absorption.
Suitability and Eligibility Differences
Both Xenical and Mysimba are typically considered for adults with a BMI of 30 kg/m² or above, or 28 kg/m² with weight-related health conditions such as type 2 diabetes or high blood pressure. However, they have different contraindications. Xenical is unsuitable for those with malabsorption syndrome or cholestasis, whilst Mysimba cannot be used by those with uncontrolled high blood pressure or eating disorders.
Your online clinical assessment will help determine which treatment may be appropriate for your circumstances. Our UK-licensed prescribers review each case individually, considering your medical history, current medications, and weight management goals.
Side Effect Profiles
The side effects differ significantly between treatments. Xenical's side effects are primarily gastrointestinal - oily stools, increased bowel movements, and abdominal discomfort, particularly when eating high-fat meals. These effects can be minimised by keeping dietary fat low (approximately 15g per meal).
Mysimba may cause different side effects including nausea, constipation, headache, and sleep disturbances. Some patients experience mood changes. Both treatments require monitoring, and you should report any persistent or concerning side effects to your healthcare provider.
Cost Comparison and Value
At EverydayMeds, orlistat offers excellent value with multiple supply options. Generic orlistat 120mg starts from £16.89 for 2 weeks, while Xenical begins at £21.50. Longer supplies provide better value - a 12-week course of generic orlistat costs £95.99 (£86.39 with EDM10). All prices include the prescription, clinical assessment, and discreet UK delivery.
Mysimba pricing varies, but orlistat generally offers a more cost-effective approach to prescription weight loss support. Use code EDM10 for 10% off every order, whether you're a new or returning customer.
Starting Your Weight Loss Journey
Both treatments work best as part of a comprehensive weight management approach. Success depends on commitment to dietary changes, regular physical activity, and consistent medication use as prescribed. Your prescriber may recommend starting with one treatment and reviewing progress after 12 weeks.
Ready to explore your options? Complete our online clinical assessment today. Our UK-licensed prescribers will review your information and determine the most suitable treatment approach. With next-day delivery available and a GPhC-registered pharmacy based in Leicester, getting started is straightforward and discreet.
