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Can You Take Metformin and Orlistat Together?
Many patients ask whether metformin and orlistat can be taken together for weight management. The answer depends on your individual health circumstances and requires assessment by a qualified prescriber. Orlistat works by blocking approximately one third of dietary fat absorption in the gut, whilst metformin primarily manages blood sugar levels and may support weight management in patients with type 2 diabetes. Our UK-licensed prescribers regularly assess combination treatments and will determine whether this approach is suitable for you.
Orlistat for Weight Loss - How It Works
Orlistat 120mg works by inhibiting lipase enzymes in your digestive system, preventing approximately one third of dietary fat from being absorbed. This unabsorbed fat passes naturally through your body. Unlike appetite suppressants that act on the brain, orlistat works locally in the gut and is not absorbed into the bloodstream in significant amounts. It must be used alongside a reduced-calorie, lower-fat diet and increased physical activity for optimal results.
Our Orlistat Options and Prices
We stock three orlistat options: generic orlistat 120mg (prescription-only), branded Xenical 120mg (prescription-only), and Alli 60mg (lower strength). Orlistat 120mg costs £32.99 for 84 capsules (4 weeks), reduced to £29.69 with discount code EDM10. Xenical 120mg costs £42.99 for the same supply (£38.69 with EDM10). Both contain identical active ingredients at the same dose - the key difference is cost. For longer treatment, our 12-week supply (252 capsules) costs £95.99 for generic orlistat or £86.39 with EDM10.
Online Prescription Process
Our streamlined process starts with completing an online health questionnaire covering your medical history, current medications including metformin, and weight management goals. A UK-licensed prescriber reviews your information and determines whether orlistat is clinically appropriate, including any interactions with existing medications. If approved, your prescription is dispensed by our GPhC-registered pharmacy in Leicester and dispatched for next-day delivery in discreet packaging.
Clinical Assessment for Combination Treatment
Taking metformin and orlistat together requires careful clinical assessment. Your prescriber will review your current metformin dose, blood sugar control, BMI, and overall health status. They'll also assess whether you meet orlistat eligibility criteria: adults with BMI ≥30 kg/m² or BMI ≥28 kg/m² with weight-related health conditions like type 2 diabetes. The assessment ensures both medications work safely together as part of your weight management programme.
Start Your Weight Loss Journey Today
Don't wait for lengthy NHS appointments. Our online prescription service provides faster access to clinically-assessed weight loss treatment. Complete our consultation now for same-day prescriber review. With 10% off every order using code EDM10, orlistat treatment becomes even more affordable. Order before 2pm for next-day delivery across the UK.


