Sildenafil Side Effects vs Spedra: Which Is Right for You?

When choosing between sildenafil and Spedra (avanafil) for erectile dysfunction treatment, understanding their side effect profiles is crucial for making an informed decision. Both medications work as PDE5 inhibitors but differ in their onset times, duration, and potential adverse effects. This comparison examines the side effects of each treatment to help you determine which option might be most suitable for your needs and lifestyle.

  • Sildenafil typically causes headaches, facial flushing, and nasal congestion in some patients
  • Spedra (avanafil) may have a lower incidence of visual disturbances compared to sildenafil
  • Both medications can interact with nitrates and blood pressure medications
  • Generic sildenafil offers the same active ingredient as Viagra at a more affordable price point
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Not sure which one? Here's the honest comparison.

Sildenafil
~60 min
~4 hrs
you like to plan ahead
Tadalafil (as-needed)Most prescribed
~30 min
up to 36 hrs
you want a whole weekend covered
Tadalafil Daily
always active
continuous
you never want to think about timing
Vardenafil
~15–30 min
~8 hrs
you want the fastest onset

How ED treatment works in your body.

Increases blood flow

Increases blood flow

When PDE5 is suppressed, blood is able to flow more freely through the body—including to the (you guessed it) penis.

Increase erections

Increase erections

More blood flow to the penis means harder, more satisfying erections once you're sexually stimulated.

Detailed Side Effect Comparison: Sildenafil vs Spedra

Understanding Sildenafil Side Effects

Sildenafil, available as both the branded Viagra and generic sildenafil, has been extensively studied since its introduction. The most commonly reported side effects include headaches (affecting approximately 16% of users), facial flushing, and nasal congestion. These effects typically occur because sildenafil affects blood vessels throughout the body, not just in the penile area.

Visual disturbances, including a blue-tinged vision or increased sensitivity to light, may affect some sildenafil users. This occurs because the medication can partially inhibit PDE6 enzymes found in the retina. Most visual effects are temporary and resolve as the medication clears from the system.

Spedra (Avanafil) Side Effect Profile

Spedra, containing the active ingredient avanafil, is a newer PDE5 inhibitor that may offer some advantages in terms of side effects. Clinical studies suggest that avanafil may have a lower incidence of visual disturbances compared to sildenafil, as it shows greater selectivity for PDE5 over PDE6 enzymes.

Common side effects of Spedra include headaches (affecting about 10% of users), back pain, and nasal congestion. The medication's faster onset time (as quick as 15-30 minutes) may appeal to those seeking spontaneity, though this doesn't necessarily correlate with fewer side effects.

Cardiovascular Considerations for Both Medications

Both sildenafil and Spedra can cause temporary decreases in blood pressure, which may lead to dizziness or lightheadedness, particularly when standing up quickly. This effect is generally more pronounced when alcohol is consumed alongside either medication.

Neither medication should be used by patients taking nitrate medications for chest pain, as this combination can cause a dangerous drop in blood pressure. Both treatments require careful evaluation of cardiovascular health before prescription.

Drug Interactions and Precautions

Sildenafil and Spedra share similar drug interaction profiles, as they belong to the same class of medications. Both can interact with alpha-blockers used for prostate problems or high blood pressure, potentially causing symptomatic hypotension.

Patients taking certain HIV medications, antifungal drugs, or antibiotics may need dose adjustments with either treatment, as these can affect how quickly the ED medication is metabolized.

Cost Considerations and Treatment Options

At EverydayMeds, patients can choose between branded Viagra and generic sildenafil, with the generic option providing significant cost savings whilst maintaining the same active ingredient and effectiveness. Spedra, being a newer branded medication, typically costs more than generic sildenafil.

The choice between treatments often depends on individual response, tolerability, and budget considerations. Some patients may find they tolerate one medication better than another, making it worthwhile to discuss alternatives with a healthcare provider if side effects prove problematic.

Making the Right Choice for Your Needs

When comparing sildenafil and Spedra side effects, it's important to remember that individual responses vary significantly. What causes side effects in one person may be well-tolerated by another. The decision should be based on your medical history, current medications, lifestyle preferences, and how you respond to initial treatment.

Both medications require a prescription following consultation with a UK-licensed prescriber who can evaluate your suitability for treatment and help you make an informed choice based on your individual circumstances.

What you need to know about erectile dysfunction

It's one of the most common conditions we treat, and one of the most treatable.

What is Erectile Dysfunction?
ED means finding it hard to get or keep an erection firm enough for sex. It's not unusual to have an off night; the point at which it's worth doing something is when it's happening regularly, or when it's starting to bother you.
How will I feel when I take ED medication?
For most men, nothing feels different day to day. The medication works in the background — when you're sexually aroused, it helps blood flow where it's needed, so erections come more easily and last longer. It doesn't cause arousal on its own. Some men notice mild, short-lived effects like a headache, facial flushing or a stuffy nose, which usually pass as the dose wears off.
Why do I need a prescription for ED medication?
ED treatments are prescription-only medicines in the UK because they aren't suitable for everyone — for example, alongside certain heart conditions or medications like nitrates. That's why we ask you to complete a short online consultation first. A UK-registered prescriber reviews your answers to make sure your chosen treatment is safe and right for you before it's dispensed.
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