Viagra Side Effects vs Tadalafil: A Complete Comparison

When considering ED medication, understanding the side effects of Viagra compared to Tadalafil is crucial for making an informed choice. Both medications belong to the PDE5 inhibitor family but have different side effect profiles and durations of action. At EverydayMeds, we offer both branded Viagra and generic sildenafil options, allowing you to choose the most suitable treatment following a clinical consultation with our UK-licensed prescribers.

  • Viagra side effects typically include headaches, facial flushing, and indigestion
  • Tadalafil may cause back pain and muscle aches more frequently than Viagra
  • Both medications can cause visual disturbances, though this is uncommon
  • Generic sildenafil offers the same side effect profile as Viagra at a lower cost
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Not sure which one? Here's the honest comparison.

Sildenafil
~60 min
~4 hrs
you like to plan ahead
Tadalafil (as-needed)Most prescribed
~30 min
up to 36 hrs
you want a whole weekend covered
Tadalafil Daily
always active
continuous
you never want to think about timing
Vardenafil
~15–30 min
~8 hrs
you want the fastest onset

How ED treatment works in your body.

Increases blood flow

Increases blood flow

When PDE5 is suppressed, blood is able to flow more freely through the body—including to the (you guessed it) penis.

Increase erections

Increase erections

More blood flow to the penis means harder, more satisfying erections once you're sexually stimulated.

Understanding Side Effects: Viagra vs Tadalafil Differences

Common Side Effects of Viagra (Sildenafil)

Viagra, containing the active ingredient sildenafil citrate, typically causes mild to moderate side effects in approximately 10-15% of users. The most frequently reported side effects include headaches (affecting up to 16% of users), facial flushing (10-13%), and indigestion or dyspepsia (7-17%). These effects are generally dose-dependent, meaning higher doses (100mg) may increase the likelihood of experiencing side effects compared to lower doses (25mg or 50mg).

Nasal congestion affects approximately 4-9% of Viagra users, whilst dizziness occurs in around 2-4% of cases. Visual disturbances, including temporary blue-tinted vision or increased light sensitivity, affect fewer than 3% of users but should be reported to your prescriber if experienced.

Tadalafil Side Effects Profile

Tadalafil, marketed under various brand names, shares many common side effects with Viagra but has some distinct differences. Headaches remain the most common side effect (affecting 11-15% of users), followed by indigestion (7-11%). However, tadalafil is more likely to cause back pain and muscle aches (myalgia) than Viagra, with these symptoms affecting up to 6% and 4% of users respectively.

The longer half-life of tadalafil (up to 36 hours compared to Viagra's 4-6 hours) means side effects may persist longer but are often milder in intensity. Facial flushing occurs less frequently with tadalafil (2-4%) compared to Viagra, making it potentially more suitable for those concerned about visible side effects.

Cardiovascular Considerations

Both medications can cause mild reductions in blood pressure, typically 5-8 mmHg systolic and 3-5 mmHg diastolic. This effect is usually well-tolerated in healthy individuals but requires careful consideration in those with cardiovascular conditions. Tadalafil may have a slightly more pronounced effect on blood pressure, particularly when combined with alcohol.

Neither medication should be taken with nitrates (such as GTN spray) as this combination can cause dangerous drops in blood pressure. Both require the same cardiovascular assessment before prescribing.

Duration and Severity Differences

Viagra's side effects typically peak 1-2 hours after taking the medication and resolve within 4-6 hours as the drug is eliminated from the system. Tadalafil's extended duration means side effects may persist for 24-36 hours, though they're often milder throughout this period.

For users who experience significant side effects with one medication, switching to the alternative may provide better tolerability whilst maintaining effectiveness for erectile dysfunction treatment.

Cost Considerations and Generic Options

At EverydayMeds, patients can choose between branded Viagra and generic sildenafil at checkout. Generic sildenafil contains the identical active ingredient and has the same side effect profile as branded Viagra but at a significantly lower cost. This makes treatment more accessible whilst maintaining the same safety and efficacy standards.

Similarly, generic tadalafil options provide the same therapeutic benefits and side effect profile as branded versions. Your choice between medications should be based on clinical suitability, lifestyle factors, and personal preferences rather than cost alone.

When to Seek Medical Advice

Whilst most side effects are mild and temporary, certain symptoms require immediate medical attention. These include prolonged erections lasting over 4 hours (priapism), sudden vision or hearing loss, chest pain, or severe allergic reactions. Regular follow-up consultations help monitor treatment effectiveness and manage any ongoing side effects.

What you need to know about erectile dysfunction

It's one of the most common conditions we treat, and one of the most treatable.

What is Erectile Dysfunction?
ED means finding it hard to get or keep an erection firm enough for sex. It's not unusual to have an off night; the point at which it's worth doing something is when it's happening regularly, or when it's starting to bother you.
How will I feel when I take ED medication?
For most men, nothing feels different day to day. The medication works in the background — when you're sexually aroused, it helps blood flow where it's needed, so erections come more easily and last longer. It doesn't cause arousal on its own. Some men notice mild, short-lived effects like a headache, facial flushing or a stuffy nose, which usually pass as the dose wears off.
Why do I need a prescription for ED medication?
ED treatments are prescription-only medicines in the UK because they aren't suitable for everyone — for example, alongside certain heart conditions or medications like nitrates. That's why we ask you to complete a short online consultation first. A UK-registered prescriber reviews your answers to make sure your chosen treatment is safe and right for you before it's dispensed.
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