SGLT2 and GLP-1 Combination: What UK Patients Should Know (October 2026)

01 · The core answer

Can you be on both an SGLT2 inhibitor and a GLP-1 medicine?

It can be possible, but whether it is right for you is a clinical decision made by a prescriber who knows your diabetes, kidney function, current medicines and history. Your own situation is what counts.

The two classes are not interchangeable. A GLP-1 medicine works on gut-hormone receptors. An SGLT2 inhibitor belongs to a different group of medicines, with its own patient leaflet, its own side effects and its own monitoring. Reading both leaflets side by side is a sensible first step before any appointment.

If you already take an SGLT2 inhibitor such as dapagliflozin and are thinking about adding a weekly injection, do not change anything on your own. Raise it with the clinician who prescribed the tablet, or with the prescriber reviewing your consultation. Our team reviews your full medicines list as part of the consultation.

02 · At a glance

How the medicines compare

Mounjaro is a GLP-1 and GIP medicine. It is not an SGLT2 inhibitor, and it does not replace one. If you are curious how the two groups compare in general terms, our guide to a GLP-1 agonist versus an SGLT2 inhibitor sets out the differences, and the page on SGLT2 and Mounjaro covers the tirzepatide side.

03 · Your next step

What to do next

If you are a private patient wanting treatment for weight management, start with a free online consultation. Be completely open about any diabetes medicines, including SGLT2 inhibitors, because they affect what the prescriber considers safe. Our weight loss clinic explains the options, and the Mounjaro pen page has more about the treatment.

If you are managing diabetes through the NHS, your diabetes team stays in charge of your diabetes medicines. Do not stop an existing tablet because you have read something online, and do not start a new injection without telling them.

Related guide: Dpp4 and glp 1 combination.

04 · How Mounjaro works

How Mounjaro works, and why it is not an SGLT2 inhibitor

Tirzepatide is the first treatment of its kind to activate two natural gut-hormone receptors at once: GIP and GLP-1.¹ Together these help regulate appetite, slow how quickly the stomach empties, and improve the way the body responds to insulin. In practice, most people feel fuller sooner and less hungry between meals, which supports a reduced-calorie diet.

That dual action is what distinguishes Mounjaro from single-action GLP-1 medicines such as semaglutide (Wegovy and Ozempic). It is also why the question "Is Mounjaro an SGLT2 inhibitor?" has a clear answer: no. Tirzepatide works through gut-hormone receptors. An SGLT2 inhibitor is a separate class with its own leaflet.

Mounjaro comes as a pre-filled multi-dose pen (KwikPen) in six strengths: 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg and 15mg. It is taken once a week. Keep pens in a fridge at 2–8°C and never freeze them. Once in use, a pen can be kept out of the fridge at a temperature not above 30°C for up to 30 days after first use, and must then be thrown away.¹³

Because the two classes act differently, reading about one does not tell you how the other behaves. Keep that in mind when you see pages that blur them together. If you want the wider picture of how GLP-1 treatments relate to other diabetes medicines, our page on GLP-1 and SGLT2 medicines is a good companion read.

05 · What trials show

What the weight-loss evidence does and does not cover

The headline tirzepatide trial is SURMOUNT-1, and it tested tirzepatide alone alongside diet and exercise. It did not test tirzepatide combined with an SGLT2 inhibitor, so it cannot tell you what a combination would do.

In the SURMOUNT-1 trial of 2,539 adults, people taking tirzepatide alongside diet and exercise lost on average 15% of their body weight on 5mg, 19.5% on 10mg and 20.9% on 15mg over 72 weeks, compared with 3.1% with lifestyle changes alone.² These are trial averages. Individual results vary, and treatment works alongside a reduced-calorie diet and increased physical activity, not instead of them.

At 72 weeks, 85% of participants on 5mg, 89% on 10mg and 91% on 15mg had lost at least 5% of their body weight. Half of participants on 10mg and 57% on 15mg lost at least 20% of their body weight.²

For a worked example only: for someone starting at 100 kg, 20.9% is about 21 kg. Trial averages do not predict your own result.

06 · Dapagliflozin questions

Dapagliflozin questions

Can dapagliflozin be used with a GLP-1 medicine? That is a prescriber's decision. The dapagliflozin patient leaflet lists medicines to tell your clinician about, and your GP or diabetes nurse can check your particular combination. Our reviewing prescriber will also ask about it during a consultation.

What should I avoid while taking dapagliflozin? The patient information leaflet that came with your supply is the authoritative list. Read the section on what to tell your doctor before taking it, and the section on possible side effects.

Does it reduce appetite or cause rapid weight loss? If you notice rapid or unexpected weight change on any medicine, speak to your prescriber or pharmacist.

How long can you stay on it? Duration is set by the clinician who prescribes it and reviews you. Never stop a long-term diabetes medicine on your own.

Ozempic or dapagliflozin? These are different classes with different jobs, and the choice belongs to you and your diabetes team. If you suspect a side effect from any medicine, you can report it through the Yellow Card scheme.¹⁹

07 · Licence and NHS access

Licence, NHS access and who Mounjaro is for

In the UK, Mounjaro is licensed for weight management in adults and for type 2 diabetes.¹ NICE has separate guidance for each use: one covering overweight and obesity, and one covering type 2 diabetes.⁴⁸

Mounjaro is available on the NHS, but access is being phased in over several years. NICE recommends it for adults with a BMI of at least 35 plus at least one weight-related condition, and the NHS primary-care rollout began in June 2025 with the highest-need groups first (initially BMI 40+ with four or more qualifying conditions).⁴⁶ Full rollout is expected to take years, which is why many people who meet the licensed criteria choose regulated private treatment rather than waiting.

If you have type 2 diabetes and are already on NHS care, your diabetes team decides what is added to your regimen. Private treatment through us is an alternative route, not a replacement for that relationship, and you should keep your team informed.

Other combinations raise similar questions. Our page on insulin with GLP-1 medicines explains the points that apply there.

08 · Preparing for a consultation

How to prepare when you take other medicines

If you take an SGLT2 inhibitor or any other diabetes medicine, a little preparation makes the consultation faster and safer. A prescriber can only judge suitability on what you tell them.

• Write down every medicine by name, including tablets, injections, insulin, creams and supplements.
• Note who prescribes each one and when it was last reviewed.
• Have your most recent diabetes review details to hand, if you have them.
• List any conditions, past reactions or allergies.
• Say whether you are pregnant, planning a pregnancy or breastfeeding. Mounjaro must not be used during pregnancy, and it should be stopped at least one month before trying to conceive. If you become pregnant during treatment, stop the medicine and tell your prescriber promptly.
• Bring your questions about combining medicines, in writing, so you do not forget them.

Our consultation is free, with no obligation. It is reviewed by a GPhC-registered prescriber, not a scoring script. Payment is taken when you place the order; if the prescriber decides the treatment is not suitable, the order is refunded automatically in full.

Repeat orders re-check suitability, so if your medicines change, for example when a new tablet is started, tell us before you reorder. We do not auto-ship.

09 · Safety and reporting

Safety, side effects and reporting

Any new symptom after starting or combining medicines deserves a conversation with your prescriber. Do not wait to see whether it passes if it worries you.

You can report suspected side effects from any medicine, including Mounjaro and SGLT2 inhibitors, through the MHRA Yellow Card scheme.¹⁹ Reports help regulators spot patterns, and anyone can make one.

Buy only from a registered pharmacy. Anyone offering to supply a prescription medicine without a consultation or prescription is a warning sign, and counterfeit medicine alerts are published by the MHRA.⁷ You can check our registration, GPhC 9012878, on the GPhC register.¹²

Mounjaro is a prescription-only medicine, supplied only after an online consultation reviewed by a GPhC-registered prescriber. It is used alongside a reduced-calorie diet and increased physical activity. Individual results vary. This page is information, not a substitute for medical advice.

10 · Serious side effects

Serious side effects: when to get help straight away

Serious side effects are uncommon but need urgent attention. Seek immediate medical help for: severe, persistent stomach pain that may spread to your back, with or without vomiting (possible pancreatitis); pain in the upper right abdomen, fever or yellowing of skin/eyes (possible gallbladder problems); or signs of a severe allergic reaction such as swelling of the face or throat and difficulty breathing. If you take insulin or a sulfonylurea alongside Mounjaro, watch for low blood sugar (shakiness, sweating, confusion) — your prescriber may need to adjust those medicines.¹

11 · How ordering works

How ordering works with us

If you decide a Mounjaro pen is worth discussing, the process is straightforward and the consultation comes first.

• Free online consultation. A short health questionnaire, with no charge and no obligation.
• Prescriber review. A GPhC-registered prescriber reviews your answers. If treatment is unsuitable, the order is refunded automatically.
• Dispensing and delivery. Our registered pharmacy dispenses, with same-day dispatch when ordered by 3pm, then free next-day tracked delivery in temperature-controlled packaging. Saturday delivery is £14.99.

Mounjaro comes through official LillyDirect supply, direct from Eli Lilly's UK distribution, as genuine KwikPens. Needles, a sharps bin and injection guidance are included with every order, and ongoing monthly reviews are part of the service.

The free GLPTrackr companion app can help you keep a record of doses and symptoms, which is useful to share at reviews.