Xenical vs Alli: Strength and Effectiveness Comparison
Dose Strength: The Key Difference
The primary difference between Xenical and Alli is the orlistat dose. Xenical contains 120mg of orlistat per capsule, whilst Alli contains 60mg - exactly half the prescription strength. Both medications work by blocking approximately one third of dietary fat absorption, but Xenical's higher dose may provide more significant fat-blocking effects when used alongside a reduced-calorie, lower-fat diet.
Prescription vs Non-Prescription Access
Xenical 120mg requires a prescription following clinical assessment by a UK-licensed prescriber. At EverydayMeds, our qualified healthcare professionals review your medical history, BMI, and suitability during an online consultation. Alli 60mg is available without prescription but still benefits from professional guidance. Both treatments work best when combined with dietary changes and increased physical activity.
Clinical Effectiveness Comparison
Due to its higher orlistat content, Xenical 120mg may support greater weight management results compared to Alli 60mg when used as part of a structured weight loss programme. However, individual responses vary significantly, and the most suitable option depends on your personal circumstances, medical history, and tolerance. Some patients prefer starting with lower-dose Alli, whilst others opt for prescription-strength Xenical following clinical assessment.
Side Effects and Tolerability
Both medications can cause gastrointestinal side effects including oily stools, increased bowel movements, and fatty discharge. These effects are directly related to dietary fat intake and the orlistat dose. Xenical's higher strength may cause more pronounced side effects, particularly when eating high-fat meals. Keeping fat intake to approximately 15g per meal significantly reduces side effects for both treatments.
EverydayMeds Pricing - Choose Your Option
As a GPhC-registered pharmacy, we offer competitive pricing on both medications. Xenical 120mg 4-week supply costs £42.99 (£38.69 with EDM10), whilst Alli 60mg 4-week supply costs £28.99 (£26.09 with EDM10). For longer treatment courses, Xenical 12-week supply is £128.99 (£116.09 with EDM10), and Alli 12-week supply is £129.99 (£116.99 with EDM10). Use code EDM10 for 10% off every order.
Which Treatment Is Right for You?
The choice between Xenical and Alli depends on several factors including your BMI, weight management goals, medical history, and previous treatment responses. Xenical may be more suitable for those seeking maximum orlistat strength following clinical assessment, whilst Alli offers a lower-dose starting option. Our UK-licensed prescribers can assess your individual circumstances during an online consultation and recommend the most appropriate treatment.
Order Safely from EverydayMeds
When you choose EverydayMeds, you're ordering from a fully regulated UK pharmacy based in Leicester. All medications are sourced through licensed pharmaceutical supply chains and dispensed by qualified pharmacy professionals. We offer next day delivery across the UK in discreet packaging, with prescription consultation included in the price. Start your clinical assessment today for professional guidance on Xenical vs Alli.


