Which Option Should You Choose: Orlistat or Xenical?
Orlistat vs Xenical: The Facts
Both Orlistat 120mg and Xenical 120mg contain the same active ingredient at identical doses. They work by blocking approximately one third of dietary fat absorption in your gut. The clinical effect is identical whether you choose generic orlistat or branded Xenical. For patients without a gallbladder, both medications require the same careful assessment by a qualified prescriber, as the mechanism of fat absorption may be different following gallbladder removal.
Price Comparison: Significant Savings Available
Generic orlistat offers substantial savings compared to branded Xenical. A 4-week supply of orlistat costs £32.99 (£29.69 with EDM10), whilst Xenical costs £42.99 (£38.69 with EDM10). Over 12 weeks, you could save over £25 by choosing generic orlistat at £95.99 (£86.39 with EDM10) compared to Xenical at £128.99 (£116.09 with EDM10). Both options include the prescription fee and are dispensed by our GPhC-registered pharmacy.
Special Considerations Without a Gallbladder
Patients without a gallbladder may have different fat digestion patterns, as bile flow is continuous rather than released with meals. This can affect how orlistat works and may influence side effects. During your online clinical assessment, our UK-licensed prescribers will review your gallbladder status alongside other health factors. Both orlistat and Xenical require the same careful evaluation, as the active ingredient and mechanism remain identical regardless of which version you choose.
Alternative Option: Alli 60mg
For those seeking a lower-strength option, Alli 60mg contains half the dose of orlistat found in prescription versions. Alli costs £28.99 for 4 weeks (£26.09 with EDM10) and may be suitable for patients wanting to start with a gentler approach. However, the clinical effect is proportionally reduced compared to 120mg formulations.
Making Your Decision
Choose generic orlistat if cost is your primary concern - you'll receive the same clinical benefit at a lower price. Some patients prefer branded Xenical for the assurance of the original manufacturer. Both options undergo the same rigorous online consultation process, where your prescriber will assess suitability based on your individual circumstances, including any history of gallbladder surgery. Complete your assessment today and save 10% with code EDM10 on your first order.


