Which Should You Choose: Orlistat or Xenical?
Orlistat vs Xenical: The Key Differences
Orlistat 120mg and Xenical 120mg are clinically equivalent medications containing the same active ingredient at identical doses. The primary difference lies in cost and branding. Generic orlistat offers substantial savings at £29.69 for a 4-week supply (with EDM10), while branded Xenical costs £38.69 for the same period. Both work by inhibiting lipase enzymes in the gut, blocking approximately one third of dietary fat absorption to support weight management alongside a reduced-calorie, lower-fat diet.
Does Orlistat Make You Tired?
Tiredness is not commonly reported as a side effect of orlistat or Xenical. The most frequent side effects are gastrointestinal, including oily stools, increased bowel movements, and abdominal discomfort. However, fatigue is listed as an uncommon side effect that may affect fewer than 1 in 10 people. If you experience persistent tiredness while taking orlistat, this could be related to dietary changes rather than the medication itself. Speak to your healthcare professional if tiredness concerns you.
Cost Comparison: Orlistat vs Xenical
Choosing generic orlistat over branded Xenical can save you approximately £108 per year. Our 12-week supply of orlistat costs £86.39 (with EDM10) compared to £116.09 for Xenical - a saving of nearly £30 per 12-week period. Both medications require the same prescription process and clinical assessment. Many patients choose generic orlistat for its cost-effectiveness, while others prefer the branded Xenical option.
Alli 60mg: The Lower-Strength Alternative
Alli 60mg contains half the dose of prescription-strength orlistat and may be suitable for those preferring a gentler starting point. At £26.09 for a 4-week supply (with EDM10), Alli provides a lower-strength option that typically produces milder gastrointestinal effects. However, the clinical effect is also reduced compared to the 120mg prescription versions.
Getting Your Prescription Online
Both orlistat and Xenical require prescription following clinical assessment by our UK-licensed prescribers. Complete our online health questionnaire covering your medical history, current medications, and weight management goals. If treatment is appropriate for you, your prescription will be issued and dispensed by our GPhC-registered pharmacy in Leicester. Next-day delivery ensures fast, discreet access to your chosen medication.
Which Option Should You Buy?
For most patients, generic orlistat 120mg provides excellent value without compromising clinical effectiveness. The monthly savings of approximately £9 compared to Xenical add up significantly over time. However, some patients prefer branded medications for personal reassurance. Both options are manufactured to the same stringent UK pharmaceutical standards and require identical clinical monitoring. Start your assessment today and save 10% with code EDM10.


