Which Should You Choose: Orlistat or Xenical?
Understanding Orlistat vs Xenical: Same Medicine, Different Price
When comparing the long-term effects of Orlistat versus Xenical, it's essential to understand that both contain identical 120mg orlistat as their active ingredient. This means both medicines work in exactly the same way - blocking approximately one third of dietary fat absorption to support weight management alongside a reduced-calorie, lower-fat diet.
The key difference lies in cost. Generic Orlistat 120mg is available from £29.69 for a 4-week supply (84 capsules) with code EDM10, while branded Xenical costs £38.69 for the same quantity. Over a 12-week treatment period, choosing Orlistat saves you approximately £27 compared to Xenical.
Long-Term Effects Profile: What to Expect
Both Orlistat and Xenical may cause identical side effects as they contain the same active ingredient at the same dose. The most common long-term considerations include gastrointestinal effects such as oily stools, increased bowel movement frequency, and potential fat-soluble vitamin deficiency if used without a multivitamin supplement.
These effects can be minimised by maintaining a lower-fat diet (approximately 15g fat per meal) and taking a daily multivitamin at bedtime. Most patients find gastrointestinal effects reduce over time as their diet adapts to the medication.
Treatment Duration and Ongoing Monitoring
Both medicines are typically prescribed for initial 12-week periods, with ongoing assessment by healthcare professionals. Long-term weight management success depends on continued adherence to dietary changes, regular physical activity, and behavioural support - the medication supports but does not replace these lifestyle modifications.
Alli 60mg: The Lower-Strength Alternative
For those preferring a gentler starting approach, Alli 60mg (half the prescription dose) is available from £26.09 for a 4-week supply. While clinically less potent than 120mg products, Alli may suit patients wanting to begin with a lower-strength option.
Fast Access Through EverydayMeds
Skip GP waiting lists with our online clinical assessment. Complete your health questionnaire, receive review by a UK-licensed prescriber, and get your prescription dispensed from our GPhC-registered Leicester pharmacy. Choose from 2, 4, 8 or 12-week supplies with next day delivery. Whether you select cost-effective Orlistat or prefer branded Xenical, both options are available with 10% off using code EDM10.
Ready to start your weight management journey? Complete our online assessment today and receive your medication tomorrow.


