Which Should You Buy: Orlistat or Xenical?
Orlistat vs Xenical: The Key Differences
When considering orlistat for weight management, you have two prescription-strength options: generic orlistat 120mg or branded Xenical 120mg. Both contain exactly the same active ingredient (orlistat) at identical 120mg doses, meaning they work in precisely the same way - by blocking approximately one third of dietary fat absorption in your digestive system.
The primary difference is cost. Generic orlistat 120mg costs £32.99 for 84 capsules (4-week supply), reduced to £29.69 with code EDM10. Branded Xenical costs £42.99 for the same quantity, reduced to £38.69 with EDM10. This represents a saving of approximately £9 per month when choosing generic orlistat.
Hair Loss Concerns with Orlistat Treatment
Some patients report hair thinning whilst taking orlistat, though this is not a commonly reported side effect in clinical trials. Hair loss may be related to weight management support rather than the medication itself, as significant calorie restriction and weight reduction can sometimes affect hair growth cycles. Additionally, orlistat may reduce absorption of fat-soluble vitamins including vitamin A, D, E and K, which could potentially impact hair health.
Whether you choose orlistat 120mg or Xenical 120mg makes no difference to potential hair effects, as both contain identical active ingredients. Taking a daily multivitamin supplement (at bedtime, at least 2 hours after your last orlistat dose) may help maintain vitamin levels during treatment.
Current Pricing Comparison
Our current pricing for both options includes:
Orlistat 120mg (Generic):
• 2 Weeks (42 capsules): £16.89 → £15.20 with EDM10
• 4 Weeks (84 capsules): £32.99 → £29.69 with EDM10
• 8 Weeks (168 capsules): £63.99 → £57.59 with EDM10
• 12 Weeks (252 capsules): £95.99 → £86.39 with EDM10
Xenical 120mg (Branded):
• 2 Weeks (42 capsules): £21.50 → £19.35 with EDM10
• 4 Weeks (84 capsules): £42.99 → £38.69 with EDM10
• 8 Weeks (168 capsules): £86.99 → £78.29 with EDM10
• 12 Weeks (252 capsules): £128.99 → £116.09 with EDM10
Alternative: Alli 60mg
For those preferring a lower-strength option, Alli 60mg provides half the dose of prescription orlistat. Whilst clinically less potent than 120mg options, Alli may cause fewer gastrointestinal side effects and could be suitable for those concerned about hair loss or other effects during initial treatment. Alli costs £28.99 for 42 capsules (4-week supply), reduced to £26.09 with EDM10.
Making Your Decision
Most patients choose generic orlistat 120mg for its cost-effectiveness, whilst others prefer branded Xenical. Both require the same online clinical assessment by our UK-licensed prescribers and work identically for weight management when used alongside a reduced-calorie, lower-fat diet. Your choice may depend on personal preference and budget considerations.
All options are dispensed by our GPhC-registered pharmacy in Leicester with next day delivery across the UK. Use code EDM10 for 10% off every order.


