Orlistat vs Xenical 120mg: Compare & Buy in the UK

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Choosing between Xenical 120mg and generic orlistat 120mg? Both contain identical active ingredients and provide the same clinical effect. The key difference is price - generic orlistat costs from £15.20 (with EDM10) compared to Xenical from £19.35 (with EDM10). Both are prescription-only medicines that work by blocking approximately one third of dietary fat absorption. Our UK-licensed prescribers can assess your suitability following an online consultation. Save 10% on every order with code EDM10. Get next day delivery from our GPhC-registered Leicester pharmacy.

  • Same active ingredient - orlistat 120mg in both products
  • Generic orlistat saves £9+ per month vs branded Xenical
  • Online prescription service - no GP appointment needed
  • Next day delivery from GPhC-registered UK pharmacy
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pricing for mounjaro and wegovy weight loss

*Pricing shown in some areas of this page may not be up to date. Please refer to the “Our Pricing Table” or the price shown after your consultation for the latest live pricing.

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Compare Prices: Generic vs Branded Orlistat

Reviewed by Mostafa Damghani · 03/07/2026

Orlistat vs Xenical: The Key Differences

Xenical 120mg capsules and generic orlistat 120mg contain exactly the same active ingredient at identical doses. Both are prescription-only medicines that work by inhibiting lipase enzymes in your digestive system, blocking approximately one third of dietary fat from being absorbed. The unabsorbed fat passes naturally through your body. Clinically, there is no difference in effectiveness between generic orlistat and branded Xenical.

Price Comparison: Why Choose Generic Orlistat?

Generic orlistat offers significant cost savings compared to branded Xenical. A 4-week supply (84 capsules) of generic orlistat costs £32.99, or £29.69 with code EDM10. The same quantity of Xenical costs £42.99, or £38.69 with EDM10. That's a saving of £9 per month by choosing generic orlistat. Over a 12-week treatment course, you could save £30+ by selecting the generic option whilst receiving identical clinical benefits.

Alli 60mg: The Lower-Strength Alternative

Alli 60mg contains half the dose of prescription-strength orlistat. This lower-strength option may be suitable for those preferring a gentler starting point, though it blocks a smaller proportion of dietary fat compared to the 120mg prescription versions. Alli 60mg costs £28.99 for a 4-week supply (42 capsules), or £26.09 with EDM10.

Who Should Choose Xenical vs Generic Orlistat?

Some patients prefer branded Xenical for the assurance of the original manufacturer (Roche), whilst others choose generic orlistat for better value. Both require the same clinical assessment and prescription process. Your choice may depend on personal preference and budget. Both products require taking one capsule three times daily with each main meal containing fat, alongside a reduced-calorie, lower-fat diet.

Online Prescription Process

Both orlistat 120mg and Xenical 120mg require a prescription following clinical assessment. Our UK-licensed prescribers can review your suitability through a secure online consultation. The process involves completing a medical questionnaire covering your BMI, medical history, and current medications. If treatment is deemed appropriate, your prescription will be dispensed by our GPhC-registered pharmacy and delivered discreetly to your address with next day delivery available.

Which Pack Size Should You Choose?

Both orlistat and Xenical are available in multiple pack sizes. For first-time users, a 2-week supply (42 capsules) allows you to assess tolerance. Most patients find a 4-week or 8-week supply more convenient and cost-effective. The 12-week supply (252 capsules) offers the best value per capsule and aligns with typical treatment duration recommendations for assessing response.

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FAQs

Frequently asked questions

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What's the difference between Xenical 120mg and generic orlistat?
Both contain identical orlistat 120mg active ingredient with the same clinical effect. The main difference is price - generic orlistat costs significantly less than branded Xenical. Choose based on your budget preference.
How much can I save choosing generic orlistat over Xenical?
Generic orlistat costs £29.69 for 4 weeks with EDM10, compared to £38.69 for Xenical. That's £9 monthly savings, or £30+ over a 12-week course by choosing generic.
Do I need a prescription for both orlistat and Xenical 120mg?
Yes, both require a prescription following clinical assessment. Our UK-licensed prescribers can review your suitability through our secure online consultation service.
Are generic orlistat capsules as effective as branded Xenical?
Yes, both contain identical active ingredients at the same 120mg dose. Generic medicines undergo strict regulatory approval to ensure equivalent clinical effectiveness to branded versions.
How quickly can I receive my orlistat or Xenical order?
Following prescriber approval, orders are dispensed by our GPhC-registered pharmacy with next day delivery available across the UK. All orders qualify for 10% off with code EDM10.