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How Orlistat Works: The Science Behind Fat Blocking
Orlistat works through a proven mechanism that blocks approximately one third of the dietary fat you consume from being absorbed into your body. The medication inhibits lipase enzymes in your digestive system, which are responsible for breaking down dietary fats. When these enzymes are blocked, the unabsorbed fat passes naturally through your body rather than being stored.
This mechanism makes orlistat different from appetite suppressants or stimulants. It acts locally in your gut and is not significantly absorbed into your bloodstream, making it a targeted approach to weight management.
Three Orlistat Options Available at EverydayMeds
We offer three clinically-proven options to suit different needs and budgets. Generic orlistat 120mg provides the most cost-effective option at £32.99 for 4 weeks (£29.69 with EDM10). Branded Xenical 120mg contains the identical active ingredient at £42.99 for 4 weeks (£38.69 with EDM10). For those preferring a lower-strength option, Alli 60mg is available at £28.99 for 4 weeks (£26.09 with EDM10).
All three products work through the same fat-blocking mechanism, with the 120mg versions blocking approximately one third of dietary fat absorption. The 60mg Alli provides a lower-dose alternative for those wanting to start with a gentler approach.
Why the Mechanism Matters for Your Weight Loss Journey
Understanding how orlistat works helps explain why it's effective when combined with a reduced-calorie, lower-fat diet. By blocking approximately one third of fat absorption, orlistat reduces the calories your body can absorb from fatty foods. This creates a calorie deficit that can support weight loss alongside dietary changes and increased physical activity.
The mechanism also explains why keeping meals low in fat (approximately 15g per meal) helps minimise gastrointestinal side effects. When you eat high-fat meals, more unabsorbed fat passes through your system, potentially causing digestive discomfort.
Your Orlistat Journey Starts with Clinical Assessment
Before you can access prescription-strength orlistat 120mg or Xenical, you'll complete an online clinical assessment reviewed by our UK-licensed prescribers. This ensures the treatment is suitable for your individual circumstances and health profile.
Our 12-week supply (252 capsules) of generic orlistat costs £95.99, reduced to £86.39 with code EDM10, providing excellent value for a complete treatment course. Xenical 12-week supply costs £128.99 (£116.09 with EDM10) for those preferring the branded option.
Next Day Delivery from Our GPhC-Registered Pharmacy
Once your prescription is approved, we'll dispense your orlistat from our GPhC-registered pharmacy in Leicester and arrange next day delivery to your address. All orders are packaged discreetly and tracked for security.
Don't wait to start your weight management journey. Now you understand how orlistat works by blocking approximately one third of dietary fat absorption, take the next step and order your treatment today using code EDM10 for 10% off.


