Choose Your Ideal Orlistat Supply Length
Does Orlistat Stop Working After a While?
Many people wonder whether orlistat becomes less effective over extended use. The medication works by blocking approximately one third of dietary fat absorption through lipase enzyme inhibition in the gut. This mechanism doesn't change with time - orlistat continues blocking the same proportion of fat throughout treatment. However, weight loss may plateau as your body adjusts to a lower weight, which is normal for any weight management approach.
2-Week Supply - Perfect for Starting Treatment
Our 2-week orlistat supply (42 capsules) costs £16.89, or just £15.20 with EDM10 discount. This shorter pack is ideal for first-time users who want to assess tolerance before committing to longer supplies. Xenical 2-week packs are £21.50 (£19.35 with EDM10). Starting with a 2-week supply allows you to monitor side effects and adjust your diet accordingly.
4-Week Supply - Standard Monthly Treatment
Our most popular option, the 4-week supply provides 84 capsules of orlistat 120mg for £32.99 (£29.69 with EDM10). Xenical 4-week packs cost £42.99 (£38.69 with EDM10), whilst Alli 60mg 4-week supplies are £28.99 (£26.09 with EDM10). This pack size suits those establishing a routine whilst maintaining flexibility.
8-Week Supply - Better Value Option
Save money with our 8-week orlistat supply (168 capsules) at £63.99, reduced to £57.59 with EDM10. That's equivalent to £28.80 per 4-week period compared to £29.69 for individual monthly packs. Xenical 8-week supplies cost £86.99 (£78.29 with EDM10), whilst Alli offers 8-week packs for £54.99 (£49.49 with EDM10).
12-Week Supply - Maximum Savings
Our 12-week orlistat supply (252 capsules) provides the best value at £95.99, just £86.39 with EDM10 discount. This works out to £28.80 per 4-week period - saving nearly £1 per week compared to monthly ordering. Xenical 12-week supplies cost £128.99 (£116.09 with EDM10), and Alli 12-week packs are £129.99 (£116.99 with EDM10). Ideal for established users confident in their treatment plan.
Maintaining Effectiveness Throughout Treatment
To ensure orlistat continues working effectively throughout your treatment period, maintain a reduced-calorie, lower-fat diet with no more than 15g fat per meal. Take one capsule with each main meal containing fat, up to three times daily. The medication's fat-blocking action remains consistent - any perceived reduction in effectiveness usually relates to dietary changes or normal weight loss plateaus rather than medication tolerance.
Order Your Preferred Supply Length Today
All pack sizes require online clinical assessment by our UK-licensed prescribers. Complete your consultation, choose your preferred supply length, and receive next-day delivery from our GPhC-registered Leicester pharmacy. Use code EDM10 for 10% off every order, whether you're choosing a 2-week trial or cost-effective 12-week supply.


