Common Aciclovir Issues & Practical Solutions
Dosage and Administration Problems
Aciclovir 400mg tablets should typically be taken five times daily for cold sores, with doses spaced evenly throughout the day. If you've missed a dose, take it as soon as you remember unless it's nearly time for your next dose. Never double up on doses. For maximum effectiveness, treatment should begin at the first signs of tingling or burning sensations. EverydayMeds stocks aciclovir 400mg tablets for those requiring prescription treatment.
Side Effects and Management
Common side effects include headaches, nausea, and skin reactions. These typically resolve without intervention. Drink plenty of water to help prevent potential kidney problems, particularly with higher doses. If you experience severe headaches, confusion, or allergic reactions, seek immediate medical attention. Most patients tolerate aciclovir well when following BNF dosing guidelines.
Treatment Not Working
If cold sores persist beyond 10 days or worsen during treatment, consult your healthcare provider. Some patients may require alternative antivirals like valaciclovir, which offers more convenient twice-daily dosing. Topical aciclovir 5% cream can be used alongside tablets for localised treatment. Stress management and avoiding known triggers may help prevent future outbreaks.
Drug Interactions and Contraindications
Aciclovir has few significant drug interactions, but inform your pharmacist about all medications you're taking. Those with kidney problems may need dose adjustments. Probenecid can increase aciclovir levels in the blood. Always check with healthcare professionals before combining treatments, especially if you're taking immunosuppressive medications.
When to Seek Further Help
Contact your GP if you experience frequent outbreaks (more than six per year), severe symptoms, or if you're immunocompromised. Some patients may benefit from suppressive therapy or stronger antiviral medications. EverydayMeds provides access to various antiviral options through our online consultation service, ensuring you receive appropriate treatment for your specific needs.






