Mounjaro vs Wegovy: Head-to-Head Comparison
The Fundamental Difference
While both are injectable weight loss treatments, they work differently:
Mounjaro (tirzepatide): Dual-action medication targeting both GIP and GLP-1 receptors - the first of its kind
Wegovy (semaglutide): Single-action medication targeting GLP-1 receptors only
This dual-action mechanism gives Mounjaro a significant advantage in clinical trials.
Weight Loss Results Compared
Mounjaro (SURMOUNT trials):
• Average weight loss: 15-22% of body weight
• Maximum dose results: Up to 22.5% weight loss
• For a 100kg patient: Potential loss of 15-22kg
Wegovy (STEP trials):
• Average weight loss: 12-15% of body weight
• Maximum dose results: Up to 15% weight loss
• For a 100kg patient: Potential loss of 12-15kg
Mounjaro consistently outperforms Wegovy by approximately 5-7 percentage points.
How Each Medication Works
Mounjaro's dual action:
• GLP-1 activation: Reduces appetite, slows stomach emptying, increases fullness
• GIP activation: Enhances insulin sensitivity, additional metabolic benefits, amplifies weight loss
• Combined effect: More comprehensive appetite control and greater fat loss
Wegovy's single action:
• GLP-1 activation: Reduces appetite, slows stomach emptying, increases fullness
• Effective but working through one pathway only
Dosing Schedules
Mounjaro: 2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg (six dose options)
Wegovy: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg (five dose options)
Both follow similar titration schedules, increasing dose every 4 weeks to minimise side effects.
UK Price Comparison
Mounjaro at EverydayMeds: From £129.99 with code FIRST40
Wegovy typical UK price: £150-300 per pen (often limited availability)
Mounjaro offers better clinical results at a competitive price, with more reliable UK supply.
Side Effect Profiles
Both medications share similar side effects:
• Nausea (most common, usually temporary)
• Reduced appetite
• Digestive changes
• Injection site reactions (mild)
Gradual dose titration helps minimise side effects with both treatments.
Which Should You Choose?
Choose Mounjaro if:
• You want maximum weight loss results
• You prefer the most clinically effective option available
• You want more dose flexibility
• You value reliable UK availability
Consider Wegovy if:
• You've had success with semaglutide before
• Your doctor specifically recommends it
For most patients prioritising results, Mounjaro is the evidence-based choice.
Get Mounjaro Today
Choose the more effective option. Order Mounjaro from EverydayMeds using code FIRST40 for £40 off. From £129.99 with next-day delivery.
