Mounjaro Loss of Sex Drive: What We Know (October 2026)

01 · The core answer

Is a loss of sex drive a Mounjaro side effect?

No, loss of sex drive does not appear in the list of recognised side effects in the Mounjaro SmPC or patient information leaflet.¹¹³ It does not mean your experience is imaginary. It means the evidence points to indirect causes rather than a direct action on desire.

02 · What to do

What should you do if your desire has dropped?

Start by noticing when it changed. A dip that begins in the days after a new dose, alongside nausea or tiredness, points to a temporary adjustment effect. A change that sits apart from dose changes, or one that does not lift, needs a proper conversation.

If you have thoughts of harming yourself or ending your life, get help straight away. Call 999 or go to A&E if you are in immediate danger. In England you can call NHS 111 and choose the mental health option, any time. You can also call Samaritans free on 116 123, day or night. Tell your prescriber about any change in your mood while taking Mounjaro.

If you are already a customer, our prescribing team offers side-effect support as part of ongoing monthly reviews.

Related guide: Does mounjaro affect sex drive.

03 · Why desire can dip

Indirect reasons desire can dip on Mounjaro

The most plausible explanations are ordinary and linked to how the medicine feels in your body, not to a direct effect on sexual function. Tirzepatide slows how quickly the stomach empties and helps you feel fuller sooner, which supports a reduced-calorie diet.¹ That change in appetite and eating pattern can touch many parts of daily life.

Digestive effects are the most common. Nausea, diarrhoea, vomiting, constipation and abdominal discomfort are the usual ones, and they are most likely when you start or move up a dose.¹³ Feeling bloated, queasy or worried about your stomach is not a recipe for feeling romantic, and that is entirely understandable.

Fatigue is also recognised. It is most noticeable in the first weeks and after dose increases, and usually reflects the body adjusting plus simply eating less.¹³ Low energy and low desire often travel together.

Finally, living through a big change in weight, routine and body image can shift how you feel about intimacy, in either direction. Some people report feeling more confident, and our page on increased sex drive on Mounjaro looks at that side of things.

04 · Side-effect timing

How long do these effects last?

Most side effects follow a pattern: they appear in the first days after starting or increasing a dose, peak early, and settle as your body adapts.¹³

For fatigue specifically, energy returns to normal for most people within a few weeks. Tell your clinical team if tiredness is severe or not settling.¹³

If a new dose is hard to tolerate, prescribers can hold the current dose longer before stepping up. Speak to your clinical team rather than pushing through severe symptoms.¹³ So if your desire dipped after an increase and you feel generally unwell, ask whether staying on your present dose for longer makes sense.

Because the medicine takes roughly four to five weeks to clear after a final dose, any effect that is truly drug-related would not vanish overnight if you stopped, and there is no way to speed this up.¹ Never stop or change dose without speaking to your prescriber first.

05 · Practical steps

What can help while you adjust

The practical steps that help most people with the digestive and energy effects are the same ones that may help you feel more like yourself.

• Eat smaller meals slowly, and stop at the first feeling of fullness.
• Favour plain lower-fat foods while you adjust.
• Stay well hydrated and avoid lying down straight after eating.
• Keep meals balanced, with protein especially, and keep gentle activity going.

If nausea or vomiting is persistent or you cannot keep fluids down, contact your clinical team — dehydration needs prompt attention.

Beyond that, talk to your partner. A drop in desire during a period of physical change is common to discuss and easier to handle when it is out in the open. Closeness that does not depend on sex can keep a relationship connected while you find your feet.

06 · Mood and wellbeing

Mood, mental health and libido

Mood and desire are closely connected, so it is worth being clear about what regulators have found. The EMA's safety committee reviewed whether these medicines are linked to low mood or suicidal thoughts and concluded in 2024 that the evidence does not support a causal link, and the MHRA keeps this under continuous review.¹⁷

That said, any big change in weight, appetite and routine can affect how you feel. Tell your prescriber about any history of depression, and seek help promptly if your mood drops or you have distressing thoughts during treatment.¹⁷

You can also report any suspected side effect, including a change in sexual interest, through the Yellow Card scheme.¹⁹ Reports from patients help regulators monitor medicines, though a report alone does not prove a medicine caused something.

07 · Other causes to consider

Other reasons your sex drive may have changed

Plenty of things unrelated to Mounjaro can lower desire, for men and women alike. Stress, poor sleep, relationship strain, low mood, tiredness, other medicines and underlying health conditions can all play a part. Timing can mislead: if you started treatment around the time something else changed in your life, the medicine may simply be the thing you noticed.

Because so many factors are involved, the useful question is not only whether Mounjaro is responsible, but what else has shifted. A GP or prescriber can go through your medicines and health history and decide whether any tests are needed. This matters most if the change is sudden, lasting, or comes with other symptoms.

For other readers' questions, see does Mounjaro make you lose sex drive, can Mounjaro reduce sex drive, and our overview of Mounjaro sex side effects.

08 · Related medicines

Before you stop or change treatment

If you take any prescription medicine, never stop it because of something you read online. Ask your prescriber or pharmacist.

Mounjaro is a prescription-only medicine, supplied only after an online consultation reviewed by a GPhC-registered prescriber, and used alongside a reduced-calorie diet and increased physical activity. Individual results vary. This page is information, not a substitute for medical advice.

09 · Serious side effects

Serious side effects: when to get help straight away

Serious side effects are uncommon but need urgent attention. Seek immediate medical help for: severe, persistent stomach pain that may spread to your back, with or without vomiting (possible pancreatitis); pain in the upper right abdomen, fever or yellowing of skin/eyes (possible gallbladder problems); or signs of a severe allergic reaction such as swelling of the face or throat and difficulty breathing. If you take insulin or a sulfonylurea alongside Mounjaro, watch for low blood sugar (shakiness, sweating, confusion) — your prescriber may need to adjust those medicines.¹