Choose Your Weight Loss Treatment: Compare & Order
Key Differences: Orlistat 120mg vs Alli 60mg
The main difference between Alli and orlistat lies in strength and prescription requirements. Orlistat 120mg requires a prescription following clinical assessment and blocks approximately one third of dietary fat. Alli contains 60mg orlistat - exactly half the prescription dose. Both contain the same active ingredient and work by inhibiting lipase enzymes in your digestive system, preventing fat absorption. Orlistat 120mg costs £32.99 for 84 capsules (£29.69 with EDM10), while Alli 60mg costs £28.99 for 42 capsules. Generic orlistat offers the most cost-effective prescription option.
Prescription Orlistat: Maximum Strength Weight Loss Support
Orlistat 120mg provides maximum clinical strength for weight management support. Available as generic orlistat from £16.89 for 42 capsules or branded Xenical from £21.50, both contain identical 120mg doses. Taking one capsule three times daily with fat-containing meals may help reduce dietary fat absorption as part of your weight management plan. Our 12-week supply (252 capsules) costs £95.99 for generic orlistat or £128.99 for Xenical, with 10% EDM10 savings reducing these to £86.39 and £116.09 respectively.
Alli 60mg: Lower Strength Option
Alli provides a lower-strength alternative at 60mg orlistat per capsule. While containing half the prescription dose, Alli still works by blocking fat absorption when used alongside a reduced-calorie, lower-fat diet. The 84-capsule pack (8 weeks) costs £54.99, reduced to £49.49 with code EDM10. Some patients prefer starting with Alli's lower strength, though prescription orlistat 120mg offers greater clinical potency for weight management support.
Clinical Assessment & Online Prescribing
Orlistat 120mg and Xenical require prescription following online clinical assessment. Our UK-licensed prescribers review your medical history, current medications, and BMI to determine treatment suitability. Generally suitable for adults with BMI 30+ or BMI 28+ with weight-related conditions like type 2 diabetes or high blood pressure. Complete our confidential health questionnaire, and if approved, your prescription is dispensed the same day from our GPhC-registered Leicester pharmacy with next day delivery included.
Maximising Your Weight Loss Results
All orlistat products work best when combined with a structured approach. Keep fat intake to approximately 15g per meal to minimise gastrointestinal side effects while maximising benefits. Take a daily multivitamin at bedtime (2 hours after your last orlistat dose) as the medication may reduce absorption of fat-soluble vitamins. Most patients find side effects reduce as their diet adapts to lower fat intake. Your treatment plan should include regular physical activity and ongoing dietary support for sustained weight management success.


