Aciclovir Dosage and Administration Guide
Standard Aciclovir Dosage for Cold Sores
The typical prescription dose for treating cold sores is 400mg taken five times daily for five days. Some healthcare providers may prescribe 200mg five times daily as an alternative regimen. Treatment should begin as soon as possible after the first symptoms appear, ideally within the first 24-48 hours when you notice tingling, itching, or burning sensations.
How to Take Aciclovir Tablets
Aciclovir tablets should be swallowed whole with a full glass of water. You can take them with or without food, though taking them with food may help reduce potential stomach upset. Space doses evenly throughout the day, approximately every 4 hours while awake. Set reminders to maintain consistent timing, as regular dosing helps maintain effective antiviral levels in your system.
Treatment Timing and Duration
Early intervention is crucial for aciclovir effectiveness. The medication works best when started during the prodromal phase - the initial tingling or burning sensation before blisters appear. Even if started after blisters develop, aciclovir may still help reduce healing time and symptom severity. Complete the full 5-day course as prescribed, even if symptoms improve earlier.
Available Treatment Options
EverydayMeds offers several cold sore treatments including aciclovir 400mg tablets and aciclovir 5% cream for topical application. Alternative antiviral options like valaciclovir 500mg tablets may be suitable for some patients, often requiring less frequent dosing. Your healthcare provider can determine the most appropriate treatment based on your individual needs and outbreak patterns.
Important Administration Notes
Stay well-hydrated whilst taking aciclovir tablets to support kidney function. If you miss a dose, take it as soon as you remember, then continue with your regular schedule. Don't double up on doses to make up for missed tablets. Store tablets at room temperature away from moisture and heat, keeping them in their original packaging until use.






