Why Understanding the Mechanism Matters for Your Purchase
How Orlistat Blocks Fat Absorption
Orlistat works by inhibiting lipase enzymes in your digestive system that normally break down dietary fat. When these enzymes are blocked, approximately one third of the fat you eat cannot be digested or absorbed into your body. This unabsorbed fat passes naturally through your digestive system, reducing the calories absorbed from fatty foods. Unlike appetite suppressants that act on the brain, orlistat works locally in the gut and is not absorbed into the bloodstream in significant amounts.
When to Take Orlistat for Maximum Effectiveness
Take one 120mg capsule three times daily with each main meal containing fat. You can take it immediately before, during, or up to one hour after eating. If you skip a meal or eat a meal with no fat, you can skip that dose. This timing ensures the medication is present when your body attempts to digest dietary fat. Generic orlistat 120mg costs £32.99 for 84 capsules (4-week supply), reduced to £29.69 with code EDM10.
Why the Mechanism Proves Orlistat Works
The fact that orlistat blocks approximately one third of fat absorption explains why it may cause gastrointestinal side effects - these are actually evidence the medication is working. When unabsorbed fat passes through your system, you might experience oily stools or increased bowel movements, particularly if you eat high-fat meals. Keeping each meal to approximately 15g fat minimises these effects while maximising weight loss support.
Comparing Your Options at EverydayMeds
You can choose generic orlistat 120mg or branded Xenical 120mg - both contain identical active ingredients at the same dose. Generic orlistat offers excellent value at £63.99 for 168 capsules (8-week supply), or £57.59 with EDM10. Xenical 120mg provides the same clinical effect at £86.99 for 8 weeks, reduced to £78.29 with discount code. Both require prescription following online clinical assessment by our UK-licensed prescribers.
Getting Started with Orlistat Today
Complete our online health questionnaire for clinical assessment by a qualified UK prescriber. If orlistat is suitable for you, we'll dispense your prescription from our GPhC-registered Leicester pharmacy with next day delivery. Understanding that orlistat blocks approximately one third of dietary fat absorption - not all fat - helps set realistic expectations for your weight management journey alongside a lower-fat diet.


