How Many mg of Tirzepatide Per Week? Dose Guide (October 2026)

01 · The core answer

The tirzepatide dose ladder, mg per week

Everyone starts Mounjaro on 2.5mg once a week. This starting dose is about letting your body adjust, not about weight loss itself. After at least four weeks the dose increases to 5mg, and can then step up by 2.5mg at a time, no sooner than every four weeks (7.5mg, 10mg, 12.5mg), up to a maximum of 15mg weekly, depending on how you respond and tolerate it.¹

Many people settle at a maintenance dose of 5mg, 10mg or 15mg. Higher is not automatically better, and your prescriber will guide the right pace.¹ For a wider view, see our guide on how much Mounjaro per week you may need.

02 · Your next step

What should I do next?

If you are already prescribed Mounjaro, follow your prescriber's titration plan rather than a general chart. If you are considering treatment, a free consultation with a GPhC-registered prescriber decides whether you are suitable and which dose to begin with. The Mounjaro pen 2.5mg starting pen has a standard price of £169.99, and our weight loss clinic explains the full process. You can also read how much Mounjaro costs per week.

03 · Pen strength and units

Pen strength, units and the dial

Mounjaro is the brand name for tirzepatide, a once-weekly injectable prescription medicine made by Eli Lilly. It comes as a pre-filled multi-dose pen (KwikPen) in six strengths: 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg and 15mg.¹ Each KwikPen contains four weekly doses.¹³

Worried about syringes or unit conversions? Mounjaro pens are dialled in mg, so see our notes on converting units to mg and 12.5mg and units.¹³

04 · Dose and weight loss

Does a higher weekly dose mean more weight loss?

In trials, average loss rose with dose, but these are averages, not predictions. In the SURMOUNT-1 trial of 2,539 adults, people taking tirzepatide alongside diet and exercise lost on average 15% of their body weight on 5mg, 19.5% on 10mg and 20.9% on 15mg over 72 weeks, compared with 3.1% with lifestyle changes alone. These are trial averages — individual results vary, and treatment works alongside a reduced-calorie diet and increased physical activity, not instead of them.²

The pace is gradual. Most measurable progress builds from 5mg onward, month by month, and the early weeks on 2.5mg are usually modest.¹ For a realistic weekly picture, read how much to lose per week and Mounjaro kg per week.

05 · Staying within the licence

Staying within the licence

The licensed maximum is 15mg weekly.

Wondering about more than one injection in a week? See Mounjaro two doses per week. If you plateau, the licensed response is to review food intake, protect protein and activity, and discuss a step-up with your prescriber if you are not yet at maximum. A plateau is not a reason to double doses or add unlicensed products.