BNF Sildenafil vs Spedra: Effectiveness Compared

When choosing between BNF-listed ED treatments, sildenafil and Spedra (avanafil) are both proven options with different profiles. Sildenafil, available as both branded Viagra and generic versions, has been treating erectile dysfunction for over 25 years. Spedra is a newer medication with potentially faster onset. Understanding their differences helps you make an informed choice about which treatment may suit your needs better.

  • Sildenafil typically starts working within 30-60 minutes and effects last 4-6 hours
  • Spedra may work faster (15-30 minutes) but duration is similar at 4-6 hours
  • Generic sildenafil offers significant cost savings compared to branded options
  • Both require sexual arousal to work and should only be taken once per day
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Not sure which one? Here's the honest comparison.

Sildenafil
~60 min
~4 hrs
you like to plan ahead
Tadalafil (as-needed)Most prescribed
~30 min
up to 36 hrs
you want a whole weekend covered
Tadalafil Daily
always active
continuous
you never want to think about timing
Vardenafil
~15–30 min
~8 hrs
you want the fastest onset

How ED treatment works in your body.

Increases blood flow

Increases blood flow

When PDE5 is suppressed, blood is able to flow more freely through the body—including to the (you guessed it) penis.

Increase erections

Increase erections

More blood flow to the penis means harder, more satisfying erections once you're sexually stimulated.

Sildenafil vs Spedra: Key Differences Explained

How Sildenafil and Spedra Work

Both sildenafil (found in Viagra) and Spedra belong to a class of medicines called PDE5 inhibitors. They work by blocking an enzyme that restricts blood flow to the penis, allowing improved circulation when sexually aroused. Neither medication causes automatic erections - sexual stimulation is still required for them to be effective.

Speed of Action: Spedra's Potential Advantage

One key difference lies in how quickly these treatments begin working. Sildenafil typically takes 30-60 minutes to become effective, whilst Spedra may start working within 15-30 minutes for some men. However, individual response times can vary significantly. Food intake, particularly fatty meals, can delay both medications' onset of action.

Duration and Effectiveness Comparison

Both treatments offer similar duration of action, with effects lasting approximately 4-6 hours. Clinical studies suggest both medications have comparable effectiveness rates for treating erectile dysfunction, with success rates typically ranging from 60-80% depending on the underlying cause and individual factors.

Side Effect Profiles

Common side effects for both medications include headache, facial flushing, nasal congestion, and indigestion. Spedra may have a slightly lower incidence of visual disturbances compared to sildenafil, though this side effect is relatively uncommon with both treatments. Most side effects are mild and temporary.

Dosage Options and Flexibility

Sildenafil is available in 25mg, 50mg, and 100mg strengths, with 50mg being the typical starting dose. Spedra comes in 50mg, 100mg, and 200mg tablets. Both allow dose adjustment based on effectiveness and tolerability, always under medical supervision.

Cost Considerations: Generic Sildenafil Advantage

Generic sildenafil offers substantial cost savings compared to both branded Viagra and Spedra. The active ingredient and effectiveness remain identical to the branded version, making it an economical choice for long-term treatment. At EverydayMeds, patients can choose between branded Viagra or generic sildenafil at checkout, allowing flexibility based on personal preference and budget.

Safety and Contraindications

Both medications share similar contraindications, including use with nitrate medications, severe cardiovascular disease, and recent heart attack or stroke. Neither should be combined with other ED treatments. A thorough medical assessment is essential before starting either treatment.

Making Your Choice

The decision between sildenafil and Spedra often depends on individual factors such as response time preferences, cost considerations, and tolerability. Many men find generic sildenafil provides excellent results at a fraction of the cost of newer alternatives. Clinical consultation helps determine the most suitable option based on your medical history and treatment goals.

What you need to know about erectile dysfunction

It's one of the most common conditions we treat, and one of the most treatable.

What is Erectile Dysfunction?
ED means finding it hard to get or keep an erection firm enough for sex. It's not unusual to have an off night; the point at which it's worth doing something is when it's happening regularly, or when it's starting to bother you.
How will I feel when I take ED medication?
For most men, nothing feels different day to day. The medication works in the background — when you're sexually aroused, it helps blood flow where it's needed, so erections come more easily and last longer. It doesn't cause arousal on its own. Some men notice mild, short-lived effects like a headache, facial flushing or a stuffy nose, which usually pass as the dose wears off.
Why do I need a prescription for ED medication?
ED treatments are prescription-only medicines in the UK because they aren't suitable for everyone — for example, alongside certain heart conditions or medications like nitrates. That's why we ask you to complete a short online consultation first. A UK-registered prescriber reviews your answers to make sure your chosen treatment is safe and right for you before it's dispensed.
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