Clinical Guidelines and Prescribing Information
Mechanism of Action
Sildenafil works as a phosphodiesterase type 5 (PDE5) inhibitor, increasing blood flow to erectile tissue when sexually stimulated. The medication does not cause automatic erections and requires sexual arousal to be effective. Effects typically begin within 30-60 minutes and may last 4-6 hours.
Dosing and Administration
The recommended starting dose is sildenafil 50mg, taken approximately one hour before sexual activity. Dosing may be adjusted to 25mg for patients requiring lower doses or increased to 100mg for enhanced effectiveness. Patients should take a maximum of one dose per 24-hour period. Food, particularly fatty meals, may delay onset of action.
Contraindications and Precautions
Sildenafil is contraindicated in patients taking nitrates due to potentially dangerous blood pressure drops. Other contraindications include severe cardiovascular disease, recent heart attack or stroke within six months, severe liver impairment, and concurrent use of riociguat. Patients with cardiovascular risk factors require careful assessment before prescribing.
Drug Interactions
Dangerous interactions occur with nitrates and riociguat. Alpha-blockers may cause hypotension when combined with sildenafil. CYP3A4 inhibitors like ketoconazole and ritonavir can increase sildenafil levels, requiring dose adjustments. Patients should inform prescribers of all current medications.
Side Effects Profile
Common side effects include headache, facial flushing, nasal congestion, and dyspepsia. Less common but serious side effects may include sudden vision loss, prolonged erections lasting over four hours, and sudden hearing loss. Patients experiencing serious side effects should seek immediate medical attention.
Choosing Between Generic and Branded Options
EverydayMeds provides both generic sildenafil and branded Viagra containing identical active ingredients. Generic sildenafil offers cost-effective treatment while maintaining the same efficacy and safety profile. Patients can choose their preferred option during the checkout process after completing our online consultation.
