Which Should You Choose: Generic Orlistat or Xenical?
Orlistat vs Xenical: The Key Differences
When comparing the best weight loss pills containing orlistat, the primary difference between generic orlistat 120mg and branded Xenical 120mg is cost. Both medications contain exactly the same active ingredient at identical doses, delivering equivalent clinical effects. Generic orlistat 120mg at EverydayMeds costs £32.99 for a 4-week supply (£29.69 with code EDM10), whilst Xenical 120mg costs £42.99 for the same period (£38.69 with EDM10). This represents savings of approximately £9 per month when choosing generic orlistat over the branded alternative.
Clinical Effectiveness - No Difference in Results
Both orlistat 120mg and Xenical 120mg work through the same mechanism, inhibiting lipase enzymes in the gut to block approximately one third of dietary fat absorption. The unabsorbed fat passes naturally through the body, supporting weight management when used alongside a reduced-calorie, lower-fat diet. Clinical studies show no difference in effectiveness between generic and branded formulations - your body cannot distinguish between them.
Pack Sizes and Pricing Comparison
EverydayMeds offers flexible pack sizes for both options. Generic orlistat 120mg is available in 42 capsules (£16.89/£15.20 with EDM10), 84 capsules (£32.99/£29.69), 168 capsules (£63.99/£57.59), and 252 capsules (£95.99/£86.39). Xenical 120mg comes in identical pack sizes at higher prices: 42 capsules (£21.50/£19.35), 84 capsules (£42.99/£38.69), 168 capsules (£86.99/£78.29), and 252 capsules (£128.99/£116.09). The 12-week supply shows the greatest savings, with generic orlistat costing nearly £30 less than Xenical.
Alternative Option: Alli 60mg
For those considering a lower-strength option, Alli 60mg contains half the dose of prescription orlistat. Available in 42 capsules for £28.99 (£26.09 with EDM10), 84 capsules for £54.99 (£49.49), and 252 capsules for £129.99 (£116.99), Alli may be suitable for individuals preferring to start with a milder treatment approach. However, the lower dose means reduced fat-blocking effect compared to prescription-strength options.
Making Your Decision
Most patients choose generic orlistat 120mg for the cost savings without compromising effectiveness. Some prefer Xenical due to brand familiarity, but both require the same online clinical assessment by our UK-licensed prescribers. Both medications have identical side effect profiles, predominantly gastrointestinal effects that can be minimised by keeping dietary fat intake low. Your choice may depend on personal preference and budget considerations.
Getting Started
Whether you choose generic orlistat or branded Xenical, the process begins with an online consultation. Our UK-licensed prescribers will assess your BMI, medical history, and suitability for treatment. If prescribed, your medication is dispensed by our GPhC-registered pharmacy in Leicester and delivered discreetly to your address with next-day delivery available. Use code EDM10 for 10% off your order, applicable to both new and returning customers.


