Can You Use Eroxon Gel With Cialis? Combination Questions Explained

• Online consultation with UK registered prescribers
• Independent prescriber review of your ED treatment
• GPhC registered UK pharmacy (registration number 9012878)
• Ongoing clinical support if your treatment needs reviewing

You should not use Eroxon gel and Cialis together unless a prescriber has specifically advised you to. Using Eroxon alongside other erectile dysfunction (ED) treatments has not been studied. The product information for tadalafil, the medicine in Cialis, advises against combining it with other ED treatments.

Eroxon contains no drug, so it has no known chemical interaction with tadalafil. That is not the same as the combination being proven safe. This guide explains why combining ED treatments is a concern, the common reasons men ask about it, what to do instead in each situation, and how to switch between Eroxon and Cialis safely.

Key things to know about topical treatment

• Do not use Eroxon and Cialis together unless a prescriber advises it.
• Using Eroxon with other ED treatments has not been studied.
• The tadalafil product information advises against combining Cialis with other ED treatments.
• Eroxon has no known drug interactions, but that does not prove the combination is safe.
• Cialis can stay active for up to 36 hours, which matters if you are switching.
• Never take more than one Cialis tablet in 24 hours.
• If one treatment is not working well enough, speak to a prescriber rather than adding another.
• An erection lasting longer than four hours needs urgent medical help.

Can Eroxon gel be used with Cialis?

Eroxon gel should not be used with Cialis unless a prescriber or doctor has advised it. Although Cialis is absorbed systemically into the bloodstream, unlike Eroxon, the combination has not been tested in clinical trials, so there is no evidence on whether it is safe, what its effectiveness or efficacy would be, or whether it offers any extra benefit for patients seeking to treat erectile dysfunction.

The table below sets out what is known and what is not.

Why has the combination not been studied?

Clinical trials usually test one treatment at a time against a comparison, such as a placebo or another treatment. The main Eroxon trials, FM57 and FM71, looked at Eroxon Stimgel as a topical gel used to treat erectile dysfunction in adult men. These clinical studies assessed Eroxon on its own, not alongside Cialis. In FM71, Eroxon and tadalafil 5mg were compared side by side, not used together.

Because no trial has tested them in combination, there is no information on how often side effects occur when both are used, or whether there is any added benefit. Eroxon is clinically proven, works within 10 minutes of application, and 63% of men experienced an erection within 10 minutes in trials. In trials, 71% of participants achieved successful intercourse within 15 minutes, and overall effectiveness was shown for 60% of men with ED. While men report fast onset and the gel stimulates nerve endings in the penis to support sexual activity, the studies still did not test combined use with tadalafil.

Does Eroxon interact with tadalafil?

Eroxon has no known chemical interaction with tadalafil, because it contains no active drug. Its ingredients are water, ethanol, propylene glycol, glycerine, carbomer and potassium hydroxide.

However, an interaction is not the only concern. Both treatments aim to increase blood flow to the penis, by different routes. Using both at once could, in theory, add to that effect. Without evidence, it is not possible to say this is safe.

Why is combining erectile dysfunction treatments a concern?

Combining ED treatments raises concerns because their effects can overlap, and oral treatments like Cialis work by blocking the PDE5 enzyme to increase blood flow to the erectile tissues, so side effects become harder to manage and an underlying problem can be missed. These concerns apply generally, not only to Eroxon and Cialis.

The main concerns are:

• Prolonged erection (priapism): combining treatments that increase blood flow may raise the risk of an erection that does not go down
• Unclear side effects: if something goes wrong, it is harder to tell which treatment caused it. Because Cialis is absorbed systemically, it can interact with other medications and cause systemic side effects, which is especially relevant for people with cardiovascular disease.
• Skin irritation: Eroxon can cause local burning, itching or soreness, which may be harder to judge alongside other effects
• Masking a problem: needing two treatments may be a sign that the cause of ED needs investigating, whether that involves blood vessels or another issue
• Lack of evidence: there is no proof that using both gives better results. Eroxon may be considered for men who cannot take oral PDE5 inhibitors such as viagra or sildenafil, but that still does not justify combining the two without advice

What is priapism, and why does it matter?

Priapism is an erection that lasts longer than four hours or is painful. It is a medical emergency, because the trapped blood can damage the tissue of the penis if not treated promptly.

Priapism is a rare but recognised side effect of PDE5 inhibitor tablets such as Cialis. Combining ED treatments without medical advice could increase the risk. If an erection lasts longer than four hours, seek urgent medical help.

Why do men ask about using Eroxon and Cialis together?

Most men who ask about combining Eroxon and Cialis want a stronger, faster or more reliable result, which often reflects concerns many men experience around timing, confidence, or self esteem. Each of these situations has a safer next step than adding a second treatment.

What if Cialis is not working as well as hoped?

If Cialis is not giving the results you expected, speak to your prescriber before trying anything else. There may be simple reasons, such as how or when the tablet is taken, or the medicine may need reviewing.

Your prescriber will determine the appropriate treatment. This may involve a different approach, strength or medicine. Never take an extra tablet to try to improve the effect, and never take more than one tablet in 24 hours.

What if you want a faster effect than Cialis gives?

Cialis usually needs at least 30 minutes to start working, and it then stays active for up to 36 hours. Eroxon is a fast acting gel that can help achieve an erection in as little as 10 minutes. That timing relates to a single dose used for one episode of sex, rather than an ongoing background effect like Cialis.

If speed is important to you, talk to your prescriber about your options. They may suggest a different approach, or a switch rather than a combination. Our comparison of Eroxon gel and Cialis explains how the two differ in speed and duration.

What if you take once-daily tadalafil?

Once-daily tadalafil keeps a steady level of the medicine in the body. Because it is always active, using Eroxon at the same time would effectively always be a combination.

If once-daily treatment is not giving enough support, speak to your prescriber. Do not add Eroxon or any other ED treatment without their advice.

If you miss a daily dose, take it when you remember, but do not take two doses in the same day.

What should you do if you are switching between Eroxon and Cialis?

If you are switching from Cialis to Eroxon, or from Eroxon to Cialis, ask a prescriber or pharmacist how to do so safely. The main consideration is how long Cialis stays active in your body.

How long does Cialis stay active?

The effect of Cialis can last up to 36 hours after taking a tablet. If you take it once daily, tadalafil remains in your body continuously.

This means that using Eroxon within this window could amount to using both treatments together. Ask your prescriber how long to wait after stopping Cialis before using Eroxon.

Eroxon, by contrast, is designed for a single use and contains no drug. Your prescriber can advise whether any waiting time is needed before starting Cialis.

How can you switch safely?

1. Speak to a prescriber or pharmacist first. Explain why you want to switch, what you are currently using, and any relationship factors that may affect which option is most suitable.
2. Stop the first treatment as advised. Do not overlap treatments unless told to.
3. Allow any recommended waiting time. This is particularly relevant after Cialis, which can stay active for up to 36 hours.
4. Start the new treatment as directed. Read the leaflet and follow your prescriber's instructions. When starting Eroxon, allow 10 minutes before intercourse for it to take effect, in line with the leaflet.
5. Give it a fair trial. Some men need a few attempts before judging a new treatment.
6. Report any side effects. Tell your prescriber, and report suspected side effects to the MHRA through the Yellow Card scheme.

What should you check if Cialis is not working well enough?

Before considering any change, check that Cialis is being used as directed. Several everyday factors can affect how well it works.

If you have checked these and Cialis is still not working well enough, speak to your prescriber. Do not take more than one tablet in 24 hours, and do not add another ED treatment without advice.

What should you check if Eroxon is not working well enough?

Eroxon does not work for every man. Before deciding it has not worked, check that it has been used as the leaflet describes, with a pea-sized amount of topical gel applied directly to the head of the penis.

Points to check:

• The full contents of one tube were used each time as a single dose; depending on pack format, guidance may describe this as a pea sized amount or pea sized amount of gel
• The gel was massaged onto the head of the penis for about 15 seconds, and this can be worked into foreplay with a partner
• The expected cooling and warming sensation was felt, as this topical treatment stimulates local nerve endings
• It was tried on a few separate occasions
• There was no ongoing irritation

Eroxon can be used with latex condoms and sexual lubricants.

If Eroxon still does not help, speak to a pharmacist or prescriber. Prescription options such as Cialis or generic tadalafil may be suitable after a clinical assessment, but they should replace Eroxon, not be added to it, unless a prescriber advises otherwise.

Who needs extra caution with ED treatments?

Some men need extra care with any ED treatment, and patients with cardiovascular disease or who have been told to avoid sex should speak to a doctor before using, switching or combining treatments.

Do not take Cialis if you:

• Take nitrates, nitric oxide donors such as amyl nitrite, or riociguat
• Have had a heart attack in the last 90 days
• Have unstable angina or chest pain during physical activity
• Have had a stroke in the last 6 months
• Have uncontrolled high or low blood pressure
• Have ever lost vision because of reduced blood flow to the optic nerve
• Have been advised to avoid physical exertion because of a heart condition

Speak to a prescriber first if you:

• Take alpha-blockers for blood pressure or prostate problems
• Take certain antifungal, antibiotic or antiviral medicines
• Take other treatment, as this medication can cause systemic effects unlike a topical option, so medical review matters
• Have a condition that increases the risk of priapism, such as sickle cell anaemia, leukaemia or multiple myeloma
• Have a deformity of the penis, such as Peyronie's disease
• Have liver or kidney problems

Do not use Eroxon if you are allergic to its ingredients, have sore, irritated or broken skin on the penis, or have a disease or deformity of the penis.

When should you seek urgent medical help?

Seek urgent medical help if:

• An erection lasts longer than four hours or is painful
• You have sudden loss of vision in one or both eyes after taking Cialis
• You have sudden loss or reduction of hearing after taking Cialis
• You have chest pain after taking Cialis. Do not take nitrates for this chest pain, and tell the medical team you have taken tadalafil
• You have signs of a serious allergic reaction, such as swelling of the face or difficulty breathing

Call 999 in an emergency. Stop using Eroxon if you have ongoing burning, itching or soreness, and speak to a pharmacist.

What side effects should you tell your prescriber?

Giving your prescriber a full picture helps them decide on the safest and most suitable treatment. Before your consultation, note down:

• Every ED treatment you have used, including Eroxon, Cialis or generic tadalafil
• How and when you used each one, and for how long
• What worked, what did not, and any side effects
• All other medicines, including over-the-counter products and supplements
• Any heart, blood pressure, liver, kidney or blood conditions
• Whether you drink alcohol, and roughly how much
• Any sexual activity concerns or relationship factors
• What matters most to you, such as speed, duration, whether you want a topical treatment, or whether you prefer to avoid oral treatments because of side effects or other medicines

Your prescriber will determine the appropriate treatment. Treatment suitability depends on an individual clinical assessment.

Medical Disclaimer

This article is for general information only and does not replace advice from a pharmacist, prescriber or other qualified healthcare professional. Do not combine, switch or stop ED treatments without professional advice. Eroxon is a medical device and Cialis is a prescription-only medicine; neither is suitable for everyone. Always read the leaflet supplied with any product. Cialis and tadalafil should only be used under the supervision of an appropriately qualified prescriber, following an individual clinical assessment. Results vary between individuals.