Orlistat vs Xenical: Which Should You Choose?
Is Xenical an Appetite Suppressant?
No, Xenical is not an appetite suppressant. Xenical contains orlistat 120mg, which works as a lipase inhibitor in your digestive system—not in your brain. It blocks approximately one third of the dietary fat you eat from being absorbed, allowing unabsorbed fat to pass naturally through your body. This mechanism is completely different from appetite suppressants that affect brain chemistry to reduce hunger.
Orlistat vs Xenical: The Key Differences
Generic orlistat 120mg and branded Xenical 120mg contain exactly the same active ingredient at identical doses. Both require a prescription and work by the same mechanism. The primary difference is cost: orlistat 84 capsules costs £32.99 (£29.69 with EDM10) versus Xenical at £42.99 (£38.69 with EDM10). Over a 12-week treatment period, choosing generic orlistat saves approximately £33 compared to Xenical whilst providing the same clinical effect.
How Both Products Work
Whether you choose orlistat or Xenical, the mechanism remains identical. Both inhibit lipase enzymes in your gut that break down dietary fat. With approximately one third of fat blocked from absorption, fewer calories enter your system. This supports weight management when used alongside a reduced-calorie, lower-fat diet and increased physical activity. Neither product affects carbohydrates, protein, or acts as an appetite suppressant.
Treatment Options Available
We stock three orlistat-based options: generic orlistat 120mg (prescription-only), branded Xenical 120mg (prescription-only), and Alli 60mg (lower-strength). For prescription-strength treatment, both orlistat and Xenical require clinical assessment. Pack sizes include 42 capsules (2-week supply), 84 capsules (4-week supply), 168 capsules (8-week supply), and 252 capsules (12-week supply). Use code EDM10 for 10% off every order.
Making Your Choice: Value vs Brand Preference
Clinically, there's no difference between generic orlistat and Xenical—both contain orlistat 120mg and provide identical effects. Some patients prefer the assurance of a branded product like Xenical, whilst others choose generic orlistat for better value. The monthly saving of approximately £9 with generic orlistat can be significant over longer treatment periods. Both options are dispensed by our GPhC-registered pharmacy following prescriber approval.
Online Prescription Process
Our UK-licensed prescribers can assess your suitability for either orlistat or Xenical through a comprehensive online consultation. Complete our medical questionnaire covering your BMI, health history, and current medications. If treatment is appropriate, your prescription will be dispensed and dispatched with next day delivery. The prescription is included in the price—no separate GP appointment required.
Who May Be Suitable
Both orlistat and Xenical may be prescribed for adults with a BMI of 30 kg/m² or above, or 28 kg/m² or above with weight-related health conditions like type 2 diabetes or high blood pressure. Final prescribing decisions are made following individual clinical assessment. Treatment must always be combined with a reduced-calorie, lower-fat diet and regular physical activity for optimal results.
