What Causes Cold Sores: Essential Checklist

Cold sores are caused by the herpes simplex virus (HSV-1), which affects up to 70% of the UK population. Understanding the triggers and risk factors can help you identify when you might be vulnerable to outbreaks. Once you know what causes cold sores, you can take preventive measures and seek appropriate antiviral treatment when needed.

  • Primary cause: Herpes simplex virus type 1 (HSV-1) infection
  • Stress and illness weaken immune system defences
  • Sun exposure and UV radiation damage lip tissue
  • Physical trauma to lips from dental work or injury
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Available Treatments

Choose from a wide range of clinically-proven, safe, and effective treatments for Cold Sore.

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Aciclovir Tablets

From £12.99

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Aciclovir 5% Cream

From £8.99

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Valaciclovir

From £18.99

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Valtrex

From £34.99

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Cold Sore Triggers and Treatment Options

Primary Viral Cause

Cold sores are primarily caused by herpes simplex virus type 1 (HSV-1), though occasionally herpes simplex virus type 2 (HSV-2) may be responsible. Initial infection typically occurs during childhood through direct contact with infected saliva, shared utensils, or kissing. The virus remains dormant in nerve cells and may reactivate throughout life, causing recurrent outbreaks.

Common Cold Sore Triggers

Several factors can trigger HSV-1 reactivation. Stress and illness compromise immune function, making outbreaks more likely. Hormonal changes during menstruation or pregnancy may trigger episodes. Sun exposure and UV radiation can damage lip tissue, whilst cold weather and wind may cause lip dryness and cracking. Physical trauma from dental procedures, lip biting, or aggressive tooth brushing can also precipitate outbreaks.

Risk Factors for Cold Sore Development

Certain individuals may be more susceptible to cold sore outbreaks. Those with compromised immune systems, including people with HIV or undergoing chemotherapy, face increased risk. Age plays a role, as initial HSV-1 infection commonly occurs before age 20. Genetic factors may influence susceptibility, whilst lifestyle factors such as poor nutrition, inadequate sleep, and excessive stress can increase outbreak frequency.

Treatment Options Available

EverydayMeds offers several antiviral treatments for cold sores. Aciclovir 400mg tablets represent the primary prescription treatment, helping to reduce outbreak duration and severity when taken early. Aciclovir 5% cream provides topical relief for localised symptoms. Valaciclovir 500mg tablets offer an alternative oral antiviral option, whilst Valtrex provides branded valaciclovir treatment. Early intervention with appropriate antiviral medication may help minimise outbreak impact.

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