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How Orlistat Works for Weight Loss
Orlistat is a prescription weight loss medication that works by inhibiting lipase enzymes in your digestive system. This blocks approximately one third of the fat you eat from being absorbed, allowing unabsorbed fat to pass naturally through your body. Unlike appetite suppressants that act on the brain, orlistat works locally in the gut and is not absorbed into the bloodstream in significant amounts. This mechanism may help reduce calorie intake from dietary fat as part of a structured weight management programme.
Orlistat vs Xenical - Choose Your Option
Generic Orlistat 120mg and branded Xenical 120mg contain identical active ingredients at the same dose, offering clinically equivalent effects. The key difference is cost - generic orlistat provides excellent value at £32.99 for 4 weeks (£29.69 with EDM10), whilst Xenical 120mg is available at £42.99 for 4 weeks (£38.69 with EDM10). Both require a prescription following clinical assessment. Some patients prefer branded Xenical whilst others choose generic orlistat for value. We also stock Alli 60mg for those preferring a lower-strength option.
Proper Usage Guidelines
Take one 120mg capsule three times daily with each main meal containing fat - immediately before, during, or up to one hour after eating. If you miss a meal or eat a fat-free meal, skip that dose. Maximum three capsules per day. For best results and minimal side effects, keep each meal to approximately 15g fat content. This approach maximises orlistat's effectiveness whilst reducing the likelihood of gastrointestinal side effects. Always take exactly as prescribed by your healthcare professional.
Who May Be Suitable
Orlistat may be suitable for adults with a BMI of 30 kg/m² or above, or those with a BMI of 28 kg/m² or above with weight-related health conditions such as type 2 diabetes, high blood pressure, or high cholesterol. Suitability is assessed through individual clinical review by UK-licensed prescribers. Treatment must always be used alongside a reduced-calorie, lower-fat diet and increased physical activity. Not suitable for pregnancy, breastfeeding, under-18s, or those with certain medical conditions.
Our Competitive Pricing
We offer transparent pricing across all pack sizes. Orlistat 120mg: 2 weeks £16.89 (£15.20 with EDM10), 4 weeks £32.99 (£29.69 with EDM10), 8 weeks £63.99 (£57.59 with EDM10), 12 weeks £95.99 (£86.39 with EDM10). Xenical 120mg: 2 weeks £21.50 (£19.35 with EDM10), 4 weeks £42.99 (£38.69 with EDM10). All prescriptions include clinical assessment - no separate GP appointment needed. Order today with code EDM10 for 10% off every purchase.
Simple Online Process
Complete our online health questionnaire covering medical history, current medications, and BMI information. A UK-licensed prescriber reviews your information and issues a prescription where clinically appropriate. Your medication is then dispensed by our GPhC-registered Leicester pharmacy and dispatched with next day delivery in discreet packaging. The entire process is regulated by MHRA standards, ensuring the same quality and safety as any UK pharmacy.


