Which Should You Choose: Orlistat or Xenical?
Orlistat vs Xenical: The Key Differences
When comparing orlistat and Xenical for prescription weight loss, it's important to understand that both medications contain identical active ingredients at the same 120mg strength. Xenical is the branded version manufactured by Roche, while orlistat is the generic equivalent. Clinically, they work identically - both block approximately one third of dietary fat absorption when used alongside a reduced-calorie, lower-fat diet.
The primary difference lies in cost. At EverydayMeds, generic orlistat 120mg costs £32.99 for a 4-week supply (£29.69 with code EDM10), while branded Xenical costs £42.99 for the same period (£38.69 with EDM10). This represents savings of approximately £9 per month when choosing generic orlistat.
How Both Medications Support Weight Management
Both orlistat and Xenical work by inhibiting lipase enzymes in your digestive system. This mechanism blocks approximately one third of the fat you eat from being absorbed, with the unabsorbed fat passing naturally through your body. This may help support weight management when combined with a structured diet and exercise programme.
Whether you choose orlistat or Xenical, you'll take one 120mg capsule three times daily with each main meal containing fat. The medication works best when daily fat intake is kept low - approximately 15g fat per meal - which also helps minimise gastrointestinal side effects.
Complete Treatment Options at EverydayMeds
We offer comprehensive prescription weight loss options to suit different preferences and budgets. Our orlistat 120mg range includes 2-week supplies (£16.89), 8-week supplies (£63.99), and 12-week supplies (£95.99). Xenical 120mg is available in the same pack sizes, starting from £21.50 for 2 weeks up to £128.99 for 12 weeks.
For those preferring a lower-strength option, we also stock Alli 60mg capsules, which contain half the dose of prescription-strength orlistat. This starts from £28.99 for a 4-week supply. All prices include 10% discount with code EDM10.
UK Online Prescription Process
Getting your prescription weight loss medication through EverydayMeds is straightforward and regulated. Complete our online health questionnaire, which covers your medical history, current medications, and weight management goals. A UK-licensed prescriber will review your information and, where clinically appropriate, issue a prescription.
Treatment suitability is assessed individually, typically for adults with a BMI of 30 kg/m² or above, or 28 kg/m² with weight-related health conditions like type 2 diabetes or high blood pressure. Your medication is then dispensed by our GPhC-registered pharmacy in Leicester and delivered discreetly to your address with next-day delivery available.
Making Your Choice
Whether you choose generic orlistat or branded Xenical depends on personal preference and budget considerations. Both require the same commitment to dietary changes and may cause similar gastrointestinal side effects, particularly when eating high-fat meals. Most patients find side effects reduce over time as they adapt to a lower-fat diet.
Start your weight management journey today by completing our online consultation. Our UK prescribers are ready to assess your suitability for prescription weight loss treatment, helping you choose between orlistat and Xenical based on your individual needs and circumstances.


