Which Weight Loss Treatment Should You Choose?
Key Differences: Orlistat 120mg vs Alli 60mg
The main difference between Alli and prescription orlistat lies in dosage and strength. Orlistat 120mg requires a prescription following clinical assessment and blocks approximately one third of dietary fat absorption. Alli 60mg is half the prescription dose, offering a lower-strength option. Both work by inhibiting lipase enzymes in the gut to reduce fat absorption when used alongside a reduced-calorie, lower-fat diet.
Prescription Orlistat 120mg - Your Options
EverydayMeds offers two prescription-strength options. Generic orlistat 120mg provides excellent value from £16.89 for 42 capsules (£15.20 with EDM10). Branded Xenical 120mg contains identical active ingredients from £21.50 for 42 capsules (£19.35 with EDM10). Both require online clinical assessment by our UK-licensed prescribers and offer the same clinical effect - the key difference is cost savings with generic orlistat.
How Each Treatment Works
All three options work through the same mechanism - blocking lipase enzymes that break down dietary fat. Prescription orlistat 120mg and Xenical 120mg may help reduce approximately one third of fat absorption per meal. Alli 60mg provides a gentler approach at half the dose. None replace the need for dietary changes - they support weight management when combined with a structured lower-fat diet and increased physical activity.
Pricing Comparison Across All Options
Generic orlistat offers the most cost-effective prescription treatment: 4-week supply (84 capsules) costs £32.99 (£29.69 with EDM10). Xenical 4-week supply costs £42.99 (£38.69 with EDM10). Alli 60mg 4-week supply costs £28.99 (£26.09 with EDM10). For 12-week treatment, orlistat costs £95.99 (£86.39 with EDM10), Xenical £128.99 (£116.09 with EDM10), and Alli £129.99 (£116.99 with EDM10).
Clinical Assessment Process
Prescription orlistat and Xenical require online clinical assessment by our qualified UK-licensed prescribers. This replaces the need for GP appointments while maintaining the same regulatory standards. Our GPhC-registered pharmacy in Leicester ensures all treatments are dispensed safely following MHRA guidelines. Alli 60mg has different eligibility criteria as the lower-strength option.
Start Your Weight Loss Journey Today
Ready to begin? Complete our confidential online assessment to determine which treatment may be suitable for you. Our prescribers will review your medical history and weight management goals. All treatments include next day delivery across the UK in discreet packaging. Use code EDM10 for 10% off your order - available for both new and returning customers.


