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When choosing between Viagra and Spedra for erectile dysfunction treatment, understanding their differences helps you make an informed decision. Both medications are effective PDE5 inhibitors that work by increasing blood flow to the penis during sexual stimulation. Viagra (sildenafil) has been trusted for over 25 years, whilst Spedra (avanafil) offers faster onset times. At EverydayMeds, we provide both branded Viagra and generic sildenafil options following consultation with our UK-licensed prescribers.
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When PDE5 is suppressed, blood is able to flow more freely through the body—including to the (you guessed it) penis.

More blood flow to the penis means harder, more satisfying erections once you're sexually stimulated.
Both Viagra (sildenafil) and Spedra (avanafil) belong to a class of medications called PDE5 inhibitors. They work by blocking the phosphodiesterase type 5 enzyme, which increases blood flow to the penis when you're sexually aroused. Neither medication causes automatic erections - sexual stimulation is still required for both to be effective.
The most significant difference between these treatments is how quickly they start working. Viagra typically takes 30-60 minutes to become effective, whilst Spedra can work within 15-30 minutes of taking it. This faster onset makes Spedra more suitable for spontaneous sexual activity.
Both medications can remain effective for 4-6 hours after taking them. This doesn't mean you'll have an erection for this entire time, but rather that you may find it easier to achieve and maintain erections during sexual activity within this timeframe.
Viagra's effectiveness can be significantly delayed by food, particularly fatty meals, which may postpone its onset by up to 2 hours. Spedra is less affected by food, making it more convenient if you prefer not to time your meals around taking medication.
Viagra is available in 25mg, 50mg, and 100mg tablets, with 50mg being the typical starting dose. Spedra comes in 50mg, 100mg, and 200mg tablets, usually starting at 100mg. Your prescriber will determine the most appropriate dose based on your medical history and response to treatment.
Both medications can cause similar side effects including headaches, flushing, indigestion, and nasal congestion. Some men may experience visual disturbances with Viagra, such as a blue tinge to vision, which is less common with Spedra. Back pain and muscle aches are occasionally reported with both treatments.
Viagra is available in both branded and generic (sildenafil) formulations. Generic sildenafil contains the same active ingredient as branded Viagra but costs significantly less. At EverydayMeds, patients can choose between branded Viagra or generic sildenafil at checkout, providing flexibility based on personal preference and budget.
Both treatments are suitable for adult men with erectile dysfunction, following consultation with a healthcare professional. They're not appropriate for everyone - particularly those taking nitrate medications for heart conditions, as this combination can cause dangerous drops in blood pressure.
The choice between Viagra and Spedra often comes down to personal preference and lifestyle factors. If you value faster onset and less food interaction, Spedra might be preferable. If you prefer a well-established treatment with generic options available, Viagra or sildenafil could be more suitable.
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