Orlistat vs Xenical: Making Your Purchase Decision
Can You Buy Orlistat Over the Counter in the UK?
Orlistat 120mg and Xenical 120mg are prescription-only medicines in the UK and cannot be purchased over the counter without clinical assessment. Both require review by a UK-licensed prescriber who will assess your suitability based on your BMI, medical history, and weight-related health factors. EverydayMeds provides online clinical assessment, making the prescription process faster and more convenient than traditional GP appointments.
Orlistat vs Xenical: What's the Difference?
The key difference between orlistat and Xenical is price, not clinical effectiveness. Generic orlistat 120mg costs £29.69 for 4 weeks with EDM10, whilst branded Xenical costs £38.69 for the same supply - a saving of £9 per month with generic orlistat. Both contain identical 120mg doses of the same active ingredient and work by blocking approximately one third of dietary fat absorption. Xenical is manufactured by Roche as the original branded version, whilst generic orlistat is produced by various licensed manufacturers to the same pharmaceutical standards.
Pricing Comparison: Orlistat vs Xenical vs Alli
Generic orlistat offers the best value for prescription-strength treatment. A 4-week supply costs £29.69 with EDM10 compared to £38.69 for equivalent Xenical. For 12-week supplies, orlistat costs £86.39 versus £116.09 for Xenical - saving £29.70 over three months. Alli 60mg provides a lower-strength alternative at £26.09 for 4 weeks with EDM10, though it blocks less dietary fat than prescription-strength options.
Which Should You Choose?
Choose generic orlistat if you want maximum value whilst receiving clinically identical treatment. The active ingredient, dose, and mechanism of action are identical to Xenical. Choose Xenical if you prefer the original branded version from Roche. Both require the same clinical assessment and work alongside a reduced-calorie, lower-fat diet. Consider Alli 60mg if you prefer starting with a lower-strength option, though it provides less dietary fat blocking than prescription doses.
How to Order Online
Complete our online clinical assessment questionnaire covering your medical history, current medications, and weight management goals. A UK-licensed prescriber reviews your information and prescribes treatment where clinically appropriate. Orders are dispensed by our GPhC-registered pharmacy in Leicester and delivered discreetly with next day delivery available. Use code EDM10 for 10% off every order.
Clinical Assessment Requirements
Orlistat and Xenical are typically prescribed for adults with BMI 30 kg/m² or above, or BMI 28 kg/m² with weight-related health conditions such as type 2 diabetes or high blood pressure. Your prescriber will assess whether treatment is suitable based on your individual circumstances. Both medicines work best when combined with a structured weight management programme including dietary changes and increased physical activity.


