Generic Orlistat vs Branded Xenical: Making Your Choice
Orlistat vs Xenical: The Clinical Facts
Generic orlistat 120mg and branded Xenical 120mg are clinically equivalent medications containing the identical active ingredient at the same dose. Both work by inhibiting lipase enzymes in your digestive system to block approximately one third of dietary fat from being absorbed. The unabsorbed fat passes naturally through your body, supporting weight management alongside a reduced-calorie, lower-fat diet.
Cost Comparison: Why Choose Generic Orlistat?
The primary difference between these medications is cost. Generic orlistat offers significant savings: a 4-week supply costs £32.99 (£29.69 with EDM10) compared to Xenical at £42.99 (£38.69 with EDM10). Over a 12-week course, you'll save £33 by choosing generic orlistat at £95.99 (£86.39 with EDM10) versus Xenical at £128.99 (£116.09 with EDM10). Both deliver identical clinical effects - the choice comes down to personal preference and budget.
Special Considerations for Crohn's Disease
If you have Crohn's disease, discussing orlistat use with a healthcare professional is particularly important. Crohn's disease affects the digestive system and can cause malabsorption issues. Since orlistat works in the gut and may affect fat-soluble vitamin absorption (A, D, E, K), your prescriber will need to assess whether this medication is suitable for your specific condition. Our UK-licensed prescribers will review your medical history during the online consultation process.
Alli 60mg: The Lower-Strength Alternative
For those preferring a gentler approach, Alli 60mg contains half the dose of prescription-strength orlistat. While less potent, it may be suitable for some patients wanting to start with lower-strength treatment. Alli costs £28.99 for a 4-week supply (£26.09 with EDM10) and doesn't require a prescription.
How to Order: Simple Online Process
Ordering is straightforward through our regulated online service. Complete our clinical questionnaire covering your medical history, current medications, and weight management goals. A UK-licensed prescriber will review your information and, if appropriate, issue a prescription. Your chosen medication is then dispensed by our GPhC-registered pharmacy and delivered discreetly to your address with next-day delivery available.
Managing Side Effects and Optimising Results
Both orlistat and Xenical may cause gastrointestinal side effects, particularly if you consume high-fat meals. Keep your fat intake to approximately 15g per meal and spread evenly across three main meals. A daily multivitamin taken at bedtime (at least 2 hours after your last dose) helps replace fat-soluble vitamins. Most patients find side effects reduce as they adapt to a lower-fat diet.
Ready to start your weight loss journey? Choose generic orlistat for maximum savings or branded Xenical if you prefer the original formulation. Use code EDM10 for 10% off your order today.


