Orlistat vs Xenical: Which Should You Choose?
Orlistat 120mg vs Xenical 120mg: The Key Facts
Orlistat and Xenical both contain exactly the same active ingredient - orlistat 120mg - which works by blocking approximately one third of dietary fat absorption. The clinical effect is identical between generic orlistat and branded Xenical. The main difference is cost: generic orlistat offers significant savings, with a 4-week supply costing £29.69 (with EDM10) compared to £38.69 for Xenical.
When to Take Orlistat 120mg - Timing is Critical
Whether you choose generic orlistat or Xenical, the dosing schedule is identical. Take one 120mg capsule three times daily with each main meal containing fat. This means taking your capsule immediately before, during, or up to one hour after breakfast, lunch, and dinner. If you skip a meal or eat a fat-free meal, you can skip that dose. This timing ensures the medication is present in your digestive system when dietary fat needs to be blocked.
Generic Orlistat 120mg - Best Value Option
Generic orlistat provides excellent value whilst delivering the same clinical benefits as branded alternatives. Available in multiple pack sizes: 2 weeks (£15.20), 4 weeks (£29.69), 8 weeks (£57.59), or 12 weeks (£86.39) - all prices with EDM10 discount. Following online clinical assessment by our UK-licensed prescribers, generic orlistat may be prescribed where clinically appropriate for adults with suitable BMI and health circumstances.
Xenical 120mg - The Branded Choice
Some patients prefer Xenical, the original branded version manufactured by Roche. Whilst more expensive than generic orlistat, Xenical offers the same orlistat 120mg dose with identical fat-blocking properties. Xenical pricing with EDM10: 2 weeks (£19.35), 4 weeks (£38.69), 8 weeks (£78.29), or 12 weeks (£116.09). The choice between generic and branded often comes down to personal preference and budget considerations.
Alli 60mg - Lower Strength Alternative
For those considering a lower-dose option, Alli contains 60mg orlistat - half the prescription strength. Whilst clinically less potent than 120mg versions, Alli may suit those preferring to start with a lower dose. Available from £26.09 for 4 weeks with EDM10 discount.
Your Online Prescription Journey
Getting your orlistat or Xenical prescription is straightforward through our GPhC-registered pharmacy. Complete our online health questionnaire, which gets reviewed by a UK-licensed prescriber. If clinically appropriate, your prescription is issued and your chosen medication dispensed for next day delivery. The prescription consultation is included in the price - no separate GP appointment needed.
Maximising Your Results
Regardless of whether you choose generic orlistat or Xenical, success depends on combining treatment with a reduced-calorie, lower-fat diet. Keep each meal to approximately 15g fat to minimise gastrointestinal side effects whilst allowing the medication to work effectively. A daily multivitamin taken at bedtime is recommended, as orlistat may reduce absorption of fat-soluble vitamins.


