Which Should You Choose: Orlistat or Xenical?
Orlistat vs Xenical: Identical Duration of Action
Both orlistat 120mg and Xenical 120mg contain the same active ingredient at identical doses, meaning their duration of action is exactly the same. Orlistat works by blocking lipase enzymes in your gut for the duration it remains in your system—typically 24-48 hours after your last capsule. Whether you choose generic orlistat or branded Xenical, you'll take one capsule three times daily with main meals containing fat, and the effect lasts until the medication clears from your digestive system.
Price Comparison: Significant Savings with Generic Orlistat
The most important difference between orlistat and Xenical is cost. Our generic orlistat 120mg costs £32.99 for 4 weeks (£29.69 with EDM10), while branded Xenical costs £42.99 for 4 weeks (£38.69 with EDM10). Over 12 weeks, you'll save £33 by choosing orlistat over Xenical—that's nearly £130 annually. Both products deliver identical clinical effects, so many patients prefer the cost-effective generic option.
Alli 60mg: The Lower-Strength Alternative
If you're considering a gentler introduction to orlistat treatment, Alli 60mg provides half the dose of prescription-strength orlistat. At £54.99 for 8 weeks (£49.49 with EDM10), Alli may cause fewer gastrointestinal side effects while still supporting weight management alongside a reduced-calorie, lower-fat diet. However, the lower dose means it blocks a smaller proportion of dietary fat compared to the 120mg prescription options.
Same Prescription Process for Both Options
Whether you choose orlistat or Xenical, both require prescription following online clinical assessment by our UK-licensed prescribers. Complete our medical questionnaire covering your BMI, health history, and current medications. If clinically appropriate, your prescription will be issued and dispensed by our GPhC-registered pharmacy in Leicester. Both medications are delivered discreetly with next day shipping across the UK.
Duration of Action: What to Expect
Orlistat's duration of action means it works while present in your digestive system—approximately one to two days after stopping treatment. This applies equally to generic orlistat and Xenical. The medication blocks approximately one third of dietary fat absorption from each meal, with unabsorbed fat passing naturally through your body. Most patients notice gastrointestinal effects (a sign the medication is working) within 24-48 hours of starting treatment.
Order Today with 10% Discount
Ready to start treatment? Use code EDM10 for 10% off your order—whether you choose cost-effective orlistat, branded Xenical, or lower-strength Alli. All three options support weight management when used alongside dietary changes and increased physical activity. Begin your clinical assessment today for next day delivery from our trusted Leicester pharmacy.


