Which Should You Buy: Orlistat or Xenical?
Orlistat vs Xenical: The Key Facts
Both orlistat 120mg and Xenical 120mg contain identical active ingredients at the same dose. Clinically, they work in exactly the same way - inhibiting lipase enzymes in your gut to block approximately one third of dietary fat from being absorbed. The unabsorbed fat passes naturally through your body. Whether you choose generic orlistat or branded Xenical, the clinical effect is equivalent.
Price Comparison: Significant Savings with Generic
The main difference between orlistat and Xenical is cost. Our generic orlistat 120mg starts from just £15.20 for 2 weeks (42 capsules) with code EDM10, compared to branded Xenical at £19.35. For a 4-week supply, you'll pay £29.69 for orlistat versus £38.69 for Xenical - saving £9 per month. Over 12 weeks, generic orlistat costs £86.39 compared to Xenical at £116.09, representing substantial savings of nearly £30.
Using Orlistat with Metformin
Many patients take orlistat alongside metformin for comprehensive weight management support. Metformin may help with blood sugar control and can support weight management in people with type 2 diabetes or insulin resistance. Orlistat works differently - blocking dietary fat absorption in the gut rather than affecting blood sugar. Our UK prescribers can assess whether combining these treatments is appropriate for your individual circumstances during your online consultation.
Alternative Option: Alli 60mg
If you prefer a lower-strength starting point, Alli 60mg contains half the dose of prescription orlistat. At £26.09 for 4 weeks with EDM10, it provides a gentler introduction to orlistat therapy with typically milder side effects. However, the clinical effect is correspondingly reduced compared to prescription-strength 120mg products.
Making Your Choice
Most patients choose generic orlistat for the cost savings, while others prefer branded Xenical. Both require the same prescription process following clinical assessment by our UK-licensed prescribers. Your choice may depend on budget, personal preference, or previous experience. Both work identically when taken three times daily with main meals containing fat, alongside a reduced-calorie, lower-fat diet.
Order Today with 10% Off
Complete our online health questionnaire for prescriber review. If approved, choose your preferred option - generic orlistat from £15.20 or branded Xenical from £19.35. All orders qualify for 10% off with code EDM10. Dispensed by our GPhC-registered pharmacy with discreet next day delivery across the UK.


