Which Should You Buy: Orlistat or Xenical?
Orlistat vs Xenical: The Key Differences
Generic orlistat 120mg and branded Xenical 120mg contain identical active ingredients at the same dose. Both work by blocking approximately one third of dietary fat absorption when taken alongside a reduced-calorie, lower-fat diet. The primary difference is cost - generic orlistat offers substantial savings without compromising clinical effectiveness.
Price Comparison: Orlistat vs Xenical
Generic orlistat provides exceptional value compared to branded Xenical. For a 4-week supply (84 capsules), orlistat costs £32.99 (£29.69 with EDM10) versus Xenical at £42.99 (£38.69 with EDM10). This represents approximately £9 monthly savings with generic orlistat. For longer-term treatment, the savings increase significantly - a 12-week supply of orlistat costs £95.99 (£86.39 with EDM10) compared to Xenical at £128.99 (£116.09 with EDM10).
Clinical Effectiveness: Identical Results
Both orlistat and Xenical work through the same mechanism - inhibiting lipase enzymes in the gut to prevent absorption of approximately one third of dietary fat. Clinical studies demonstrate equivalent effectiveness between generic and branded formulations when used alongside appropriate dietary changes. Individual responses vary, but the active ingredient concentration and absorption profile remain identical.
Consider Alli 60mg as an Alternative
For those preferring a lower-strength option, Alli 60mg provides half the dose of prescription-strength orlistat. Available in 4-week supplies from £28.99 (£26.09 with EDM10), Alli may be suitable for individuals seeking a gentler introduction to orlistat therapy, though clinical effectiveness is proportionally reduced.
Online Prescription Process
Both orlistat and Xenical require prescription following clinical assessment by UK-licensed prescribers. Complete our online health questionnaire covering medical history, current medications, and BMI information. If clinically appropriate, your prescription is issued and dispensed by our GPhC-registered pharmacy. Treatment suitability depends on individual circumstances - not everyone will be eligible.
Managing Side Effects and Diet
Both medications may cause gastrointestinal side effects, particularly when consuming high-fat meals. Keep dietary fat intake to approximately 15g per meal to minimise side effects significantly. A daily multivitamin taken at bedtime is recommended, as orlistat may reduce absorption of fat-soluble vitamins. Most side effects reduce over time as diet adapts.
Order Today with Free Next Day Delivery
Choose generic orlistat for maximum value or branded Xenical if you prefer the original formulation. Both options include prescription, clinical assessment, and discreet next day delivery. Use code EDM10 for 10% off every order. Start your weight management journey with clinically proven orlistat therapy from our Leicester-based GPhC-registered pharmacy.


