Orlistat vs Xenical: Which Should You Choose?
Can You Take Ibuprofen With Orlistat and Xenical?
Both generic orlistat 120mg and branded Xenical 120mg contain exactly the same active ingredient at identical doses. This means their compatibility with ibuprofen is the same—there are no known significant interactions between orlistat and ibuprofen. However, always consult your prescriber before combining any medications, especially if you have underlying health conditions or take regular medications.
Generic Orlistat vs Branded Xenical: The Key Differences
The primary difference between orlistat and Xenical is price. Generic orlistat 120mg from £29.69 (4-week supply with EDM10) offers identical clinical effects to Xenical at £38.69—that's £9 monthly savings. Both work by blocking approximately one third of dietary fat absorption and require the same reduced-calorie, lower-fat diet alongside treatment.
Orlistat Pricing and Pack Sizes
Generic orlistat 120mg: 2-week supply (42 capsules) £15.20, 4-week supply (84 capsules) £29.69, 8-week supply (168 capsules) £57.59, 12-week supply (252 capsules) £86.39. All prices include 10% discount with code EDM10. Take one capsule three times daily with each main meal containing fat.
Xenical Pricing Comparison
Branded Xenical 120mg: 2-week supply £19.35, 4-week supply £38.69, 8-week supply £78.29, 12-week supply £116.09 (with EDM10). While clinically identical to generic orlistat, Xenical costs approximately £30 more per 12-week course. Some patients prefer branded medication, while others choose generic for value.
Alli 60mg: Lower-Strength Alternative
Alli contains half the orlistat dose (60mg) and is available as a lower-strength option. 4-week supply from £26.09, 8-week supply £49.49, 12-week supply £116.99 (with EDM10). While less potent than prescription-strength orlistat, Alli may suit those preferring a gentler starting approach.
Pain Relief Guidance While Taking Orlistat
Ibuprofen can generally be used alongside orlistat or Xenical, but timing matters. Take ibuprofen with food as usual, but consider the fat content of meals to minimise orlistat-related gastrointestinal effects. Your prescriber will provide personalised guidance on combining medications safely and effectively during your clinical assessment.
Online Prescription Process
Complete our clinical assessment questionnaire online, reviewed by UK-licensed prescribers who will determine treatment suitability and provide medication compatibility guidance. Following prescriber approval, your chosen treatment is dispensed by our GPhC-registered Leicester pharmacy with next day delivery available across the UK.


