Generic vs Branded: Making Your Choice
Orlistat vs Xenical: The Key Differences
When comparing Orlistat 120mg and Xenical 120mg, the most important fact is that both contain exactly the same active ingredient at the same dose. Xenical is the original branded version manufactured by Roche, whilst Orlistat is the generic equivalent. Clinically, they work identically - both block approximately one third of dietary fat absorption when taken with meals containing fat.
The primary difference is cost. A 4-week supply of generic Orlistat costs £32.99 (£29.69 with EDM10), compared to Xenical at £42.99 (£38.69 with EDM10). Over 12 weeks, you could save approximately £30 by choosing generic Orlistat over branded Xenical.
Which Should You Buy?
For most patients, generic Orlistat 120mg offers the best value without compromising effectiveness. Both products require a prescription following clinical assessment, work through the same mechanism, and have identical side effect profiles. Some patients prefer the reassurance of the original branded Xenical, whilst others choose generic Orlistat for the significant cost savings.
Your choice may depend on personal preference and budget. Both are dispensed by our GPhC-registered pharmacy following prescriber approval, with the same next-day delivery service and quality assurance.
Alli 60mg: The Lower-Strength Alternative
For those considering a gentler start, Alli 60mg provides half the dose of prescription-strength orlistat. At £49.49 for an 8-week supply (with EDM10), Alli may suit those preferring lower-strength treatment, though it blocks a smaller proportion of dietary fat compared to the 120mg prescription options.
Cost Comparison: Your Savings Breakdown
Our current pricing with EDM10 discount shows clear savings with generic Orlistat. For a 12-week supply, Orlistat costs £86.39 compared to Xenical at £116.09 - a saving of nearly £30. Even for shorter courses, the savings add up: 2-week supplies cost £15.20 for Orlistat versus £19.35 for Xenical.
All prices include the prescription - no separate GP appointment fees. Use code EDM10 at checkout for 10% off every order, available to both new and returning customers.
The Prescription Process
Both Orlistat and Xenical require clinical assessment by a UK-licensed prescriber. Our online consultation takes minutes to complete, covering your medical history, current medications, and weight management goals. Treatment is prescribed where clinically appropriate for adults with suitable BMI levels alongside weight-related health considerations.
Following prescriber approval, your chosen treatment is dispensed by our Leicester-based GPhC-registered pharmacy and delivered discreetly with next-day tracked delivery across the UK.
How Both Products Work
Whether you choose Orlistat or Xenical, the mechanism remains identical. Both work locally in your digestive system, inhibiting lipase enzymes that break down dietary fat. This prevents approximately one third of the fat you eat from being absorbed, with the unabsorbed fat passing naturally through your body.
Both must be taken alongside a reduced-calorie, lower-fat diet and regular physical activity for optimal results. Most patients find keeping meals to around 15g fat helps minimise gastrointestinal side effects whilst maximising the weight management benefits.


