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How Orlistat Blocks Fat Absorption
Orlistat works through a targeted mechanism in your digestive system. The medicine inhibits lipase enzymes responsible for breaking down dietary fat, preventing approximately one third of the fat you eat from being absorbed into your body. This unabsorbed fat passes naturally through your digestive system, reducing calorie intake from dietary fat as part of your weight management plan.
Why One Third Fat Blocking Matters
Understanding that orlistat blocks approximately one third of dietary fat helps explain why it's clinically effective for weight management. This mechanism means you absorb fewer calories from fatty foods while still maintaining normal digestion of proteins and carbohydrates. The precise targeting of fat absorption makes orlistat a valuable tool alongside your reduced-calorie, lower-fat diet.
Orlistat vs Xenical vs Alli: Same Mechanism, Different Strengths
All three products work through identical fat-blocking mechanisms. Orlistat 120mg (£29.69 for 4 weeks with EDM10) and Xenical 120mg (£38.69 with EDM10) contain the same dose and block approximately one third of dietary fat equally effectively. Alli 60mg (£26.09 with EDM10) uses half the dose, blocking a smaller proportion of fat. Choose based on your budget and strength preference following clinical assessment.
The Science Behind Local Action
Orlistat's effectiveness comes from its local action in the gut rather than systemic absorption. The medication works where digestion happens, inhibiting pancreatic and gastric lipases without significant absorption into your bloodstream. This targeted approach means the fat-blocking effect occurs precisely where dietary fat would normally be broken down and absorbed.
Proven Mechanism for Weight Management
Clinical studies demonstrate orlistat's fat-blocking mechanism supports weight loss when combined with a reduced-calorie, lower-fat diet. The approximately one third reduction in dietary fat absorption translates to meaningful calorie reduction over time. This proven mechanism gives you confidence that orlistat works through established science, not empty promises.
Order Your Supply Today
Now you understand how orlistat blocks approximately one third of dietary fat, you can make an informed decision about starting treatment. Our online clinical assessment takes minutes, and UK-licensed prescribers review your suitability the same day. With next-day delivery and 10% off every order using code EDM10, there's no reason to delay starting your weight management journey.


