Understanding Orlistat's Fat-Blocking Mechanism
How Orlistat Blocks Fat Absorption
Orlistat works through a scientifically proven mechanism that inhibits lipase enzymes in your digestive system. These enzymes are responsible for breaking down dietary fat so it can be absorbed by your body. When orlistat blocks these enzymes, approximately one third of the fat you eat cannot be digested or absorbed. This unabsorbed fat passes naturally through your digestive system and is eliminated from your body.
This mechanism means orlistat acts locally in your gut rather than affecting your brain or nervous system. The remaining two thirds of dietary fat is still absorbed normally, which is why following a reduced-calorie, lower-fat diet is essential for both effectiveness and minimising side effects.
Why This Mechanism Works for Weight Loss
By blocking approximately one third of dietary fat absorption, orlistat reduces the calories your body absorbs from fat. Since fat contains 9 calories per gram (compared to 4 calories per gram for carbohydrates and protein), this fat-blocking action can significantly reduce your overall calorie intake when combined with appropriate dietary changes.
At EverydayMeds, we supply orlistat 120mg from £29.69 for a 4-week supply (with code EDM10), making this clinically proven fat-blocking mechanism accessible through our regulated online pharmacy service.
Orlistat vs Xenical vs Alli - Same Mechanism, Different Strengths
All three products work through the same fat-blocking mechanism, but at different strengths. Orlistat 120mg and Xenical 120mg contain identical active ingredients and provide the same fat-blocking effect - orlistat offers better value at £29.69 per month compared to Xenical at £38.69 (both with EDM10). Alli 60mg contains half the dose, blocking a smaller proportion of dietary fat, available from £26.09 for 4 weeks.
What to Expect When Orlistat Works
The fat-blocking mechanism becomes apparent through gastrointestinal effects, particularly if you eat high-fat meals. These effects - including oily stools, increased bowel frequency, and oily spotting - are actually signs that orlistat is working by preventing fat absorption. Keeping meals to approximately 15g fat each significantly reduces these effects while maintaining the weight loss benefits.
Following an online clinical assessment with our UK-licensed prescribers, you'll receive detailed guidance on how to work with orlistat's mechanism for optimal results.
Order Orlistat Online Today
Now you understand how orlistat's fat-blocking mechanism works, you can access this proven weight loss medication through EverydayMeds' GPhC-registered pharmacy. Choose from orlistat 120mg (£29.69/month), Xenical 120mg (£38.69/month), or Alli 60mg (£26.09/month) - all prices with EDM10 discount. Complete your online consultation today for next-day delivery across the UK.


