Why Orlistat's Fat-Blocking Mechanism Works
How Orlistat Blocks Fat - The Science That Proves It Works
Orlistat's effectiveness lies in its unique mechanism of action. Unlike appetite suppressants that affect the brain, orlistat works locally in your digestive system by inhibiting pancreatic and gastric lipase enzymes. These enzymes are responsible for breaking down dietary fat into smaller molecules that can be absorbed. When orlistat blocks these enzymes, approximately one third of the fat you eat cannot be digested or absorbed into your body.
This unabsorbed fat passes naturally through your digestive system and is eliminated. The remaining two thirds of dietary fat is processed normally, which is why orlistat works best alongside a reduced-calorie, lower-fat diet. This proven mechanism makes orlistat a clinically validated approach to weight management when prescribed following individual assessment.
Compare Your Orlistat Options
EverydayMeds stocks three orlistat options, each using the same fat-blocking mechanism. Generic orlistat 120mg offers excellent value at £32.99 for 4 weeks (£29.69 with EDM10). Xenical 120mg provides the same clinical effect as the branded option at £42.99 for 4 weeks (£38.69 with EDM10). Alli 60mg offers a lower-strength option at £28.99 for 4 weeks (£26.09 with EDM10).
All three products work by blocking approximately one third of dietary fat absorption. The 120mg prescription strength (orlistat and Xenical) provides maximum fat-blocking potential, while Alli 60mg blocks a smaller proportion of dietary fat. Your choice depends on your clinical needs and budget preferences.
Buy Orlistat Online - Simple Process
Understanding how orlistat works is the first step - buying it online is straightforward. Complete our medical questionnaire covering your weight management history, current medications and BMI details. A UK-licensed prescriber reviews your information and, if clinically appropriate, issues your prescription. Our GPhC-registered Leicester pharmacy then dispenses and dispatches your orlistat with next day delivery across the UK.
Orlistat 120mg prices include the online consultation and prescription - no separate GP fees. Choose from 2-week starter packs (42 capsules, £16.89) up to 12-week supplies (252 capsules, £95.99). Apply code EDM10 at checkout for 10% off every order, making 12 weeks cost just £86.39.
Maximise Orlistat's Fat-Blocking Effect
Since orlistat blocks approximately one third of dietary fat, keeping meals low in fat optimises both effectiveness and comfort. Aim for no more than 15g fat per meal spread across three daily meals. Higher fat meals increase the likelihood of gastrointestinal side effects as more unabsorbed fat passes through your system.
Take one 120mg capsule with each main meal containing fat, up to three times daily. If you miss a meal or eat a fat-free meal, skip that dose. A daily multivitamin taken at bedtime (at least 2 hours after your last orlistat dose) helps maintain fat-soluble vitamin levels while the medication blocks fat absorption.


