Which Should You Choose: Orlistat or Xenical?
Orlistat vs Xenical: The Clinical Facts
Both Orlistat 120mg capsules and Xenical 120mg capsules contain exactly the same active ingredient – orlistat – at identical doses. They work through the same mechanism, blocking approximately one third of dietary fat absorption in the gut when taken with meals. The clinical effect is equivalent whether you choose generic Orlistat or branded Xenical from Roche.
Price Comparison: Significant Savings with Generic Orlistat
The primary difference lies in cost. Generic Orlistat 120mg costs £32.99 for a 4-week supply (£29.69 with EDM10), while branded Xenical costs £42.99 (£38.69 with EDM10) – that's approximately £9 monthly savings with the generic option. For longer treatment periods, these savings become substantial: 12-week supplies cost £95.99 for Orlistat versus £128.99 for Xenical before discount.
Alli 60mg: Lower-Strength Alternative
Alli contains half the dose of prescription-strength orlistat at 60mg per capsule. While clinically less potent than the 120mg options, it may suit those preferring a lower-strength starting point. A 4-week supply costs £28.99 (£26.09 with EDM10). However, the reduced dose means it blocks a smaller proportion of dietary fat compared to prescription-strength options.
How All Three Products Work
Whether you choose Orlistat, Xenical, or Alli, the mechanism remains the same. Each works by inhibiting lipase enzymes in the digestive system, preventing approximately one third of dietary fat from being absorbed. This unabsorbed fat passes naturally through the body. All must be used alongside a reduced-calorie, lower-fat diet and regular physical activity for optimal results.
Online Prescription Process
Both Orlistat 120mg and Xenical 120mg require prescription following clinical assessment. Complete our online health questionnaire, reviewed by UK-licensed prescribers who determine treatment suitability. If appropriate, your prescription is dispensed by our GPhC-registered pharmacy in Leicester and delivered discreetly with next-day tracked shipping.
Making Your Decision
Choose generic Orlistat 120mg for maximum value – identical clinical effect at the lowest cost. Opt for branded Xenical if you prefer the original manufacturer's product. Consider Alli 60mg if you want to start with a lower dose. All options include 10% discount with code EDM10, making effective weight management support more affordable.


