Why Understanding Orlistat's Mechanism Matters
How Orlistat 120mg Capsules Block Dietary Fat
Orlistat works by inhibiting lipase enzymes in your digestive system. These enzymes normally break down dietary fat so it can be absorbed into your bloodstream. When orlistat blocks approximately one third of these enzymes, the corresponding fat cannot be digested or absorbed. Instead, this unabsorbed fat passes naturally through your body and is eliminated. This mechanism means orlistat acts locally in your gut rather than affecting your brain or central nervous system like some other weight management approaches.
Why "Approximately One Third" Matters
Orlistat blocks approximately one third of dietary fat absorption - not all fat. This precise mechanism has been extensively studied in clinical trials. The remaining two thirds of dietary fat is still absorbed normally, which is why orlistat must be combined with a reduced-calorie, lower-fat diet for optimal results. Understanding this helps explain why keeping meals low in fat (around 15g per meal) minimises side effects while maximising the treatment's effectiveness.
Comparing Your Orlistat Options
All orlistat 120mg products work identically - whether you choose generic orlistat or branded Xenical, you get the same active ingredient blocking the same proportion of dietary fat. Generic orlistat 120mg costs £32.99 for 4 weeks (£29.69 with code EDM10), while Xenical 120mg costs £42.99 for 4 weeks (£38.69 with EDM10). Alli 60mg contains half the dose, blocking a smaller proportion of dietary fat. Your prescriber will determine which strength is most appropriate following your clinical assessment.
What Happens to Blocked Fat
The approximately one third of dietary fat that orlistat blocks cannot be stored as body fat because it's never absorbed. This unabsorbed fat travels through your digestive system and is eliminated naturally. This process may cause gastrointestinal side effects, particularly if you eat high-fat meals. However, these effects are actually evidence that the medication is working as intended. Most patients find side effects reduce significantly when they follow the recommended low-fat diet.
Getting Started with Orlistat
Now you understand how orlistat blocks approximately one third of dietary fat absorption, you can make an informed decision about treatment. Our online clinical assessment takes minutes to complete, and our UK-licensed prescribers review every application individually. If orlistat is suitable for you, we'll dispense your prescription from our GPhC-registered pharmacy in Leicester and arrange next day delivery. Use code EDM10 for 10% off every order, whether you're a new or returning customer.
