Orlistat vs Xenical: Which Should You Buy?
Generic Orlistat vs Xenical: Clinical Equivalence
If you're wondering why you're not losing weight on orlistat, switching between generic orlistat and branded Xenical won't solve the issue—they contain identical active ingredients at the same 120mg dose. Both medications work by inhibiting lipase enzymes in your digestive system, blocking approximately one third of dietary fat from being absorbed. The unabsorbed fat passes naturally through your body, reducing calorie intake when used alongside a reduced-calorie, lower-fat diet.
Price Comparison: Significant Savings Available
The main difference between orlistat and Xenical is cost. Generic orlistat 120mg costs £32.99 for 4 weeks (£29.69 with EDM10), while branded Xenical costs £42.99 for 4 weeks (£38.69 with EDM10). Over 12 weeks, you'll save £33 by choosing generic orlistat—that's £86.39 vs £116.09 with our EDM10 discount code. Both are prescription-only medicines requiring clinical assessment by our UK-licensed prescribers.
Why Weight Loss May Not Be Happening
If you're not losing weight on either orlistat or Xenical, consider these factors: Are you following a reduced-calorie, lower-fat diet with no more than 15g fat per meal? Are you taking one capsule with each main meal containing fat? High-fat meals not only increase side effects but reduce the medication's effectiveness. Both orlistat and Xenical work best when combined with lifestyle changes—they're not magic solutions but tools to support weight management.
Alli 60mg: Lower-Strength Alternative
For those experiencing side effects with 120mg strength, Alli 60mg offers half the dose. At £26.09 for 4 weeks (with EDM10), Alli may be suitable if you prefer starting with lower-strength treatment. However, Alli blocks a smaller proportion of dietary fat compared to prescription-strength orlistat or Xenical.
Making Your Choice: Value vs Brand Preference
Choose generic orlistat 120mg if you want clinically equivalent treatment at the lowest cost—from £15.20 for 2 weeks with EDM10. Choose Xenical 120mg if you prefer branded medication from Roche—from £19.35 for 2 weeks with EDM10. Both require the same online clinical assessment, both are dispensed by our GPhC-registered pharmacy in Leicester, and both qualify for next day delivery across the UK.
Order Online Today
Complete our online health questionnaire for clinical review by UK-licensed prescribers. If approved, your chosen treatment will be dispensed and dispatched for next day delivery. Remember to use code EDM10 for 10% off every order—new and returning customers welcome.


