Which Should You Choose: Generic Orlistat or Xenical?
Orlistat vs Xenical: The Clinical Facts
Both orlistat 120mg and Xenical 120mg contain exactly the same active ingredient at identical doses. Clinically, they work in precisely the same way - inhibiting lipase enzymes in your gut to block approximately one third of dietary fat absorption. The unabsorbed fat passes naturally through your digestive system. Whether you choose generic orlistat or branded Xenical, you'll follow the same dietary guidelines and experience the same clinical effects.
Price Comparison: Significant Savings Available
The main difference between these medications is cost. Generic orlistat 120mg costs £32.99 for 84 capsules (4-week supply), reduced to £29.69 with code EDM10. Xenical 120mg costs £42.99 for the same quantity, reduced to £38.69 with EDM10. This represents a saving of approximately £9 per month by choosing generic orlistat. For a 12-week supply, you save £30 with generic orlistat at £86.39 versus Xenical at £116.09.
What You Can Eat on Both Medications
Dietary requirements are identical whether taking orlistat or Xenical. Keep each main meal to approximately 15g fat or less - this typically means grilled chicken breast, steamed vegetables, lean fish, wholemeal pasta with tomato-based sauces, and fresh fruit. High-fat meals significantly increase gastrointestinal side effects like oily stools and urgent bowel movements. Both medications work best alongside a reduced-calorie, lower-fat diet with regular physical activity.
Alli 60mg: The Lower-Strength Alternative
If you prefer starting with a lower dose, consider Alli 60mg capsules. At half the strength of prescription orlistat, Alli typically produces milder side effects whilst still supporting weight management. Alli costs £26.09 for a 4-week supply with EDM10. The same dietary guidelines apply - keep fat intake low to maximise effectiveness and minimise side effects.
Making Your Decision
Choose generic orlistat 120mg if you want the most cost-effective option with identical clinical benefits. Choose Xenical 120mg if you prefer the branded version from Roche. Both require prescription following our online clinical assessment by UK-licensed prescribers. Consider Alli 60mg if you want to start with lower-strength treatment. All options are available with 10% discount using code EDM10, delivered next day from our GPhC-registered pharmacy in Leicester.


