Orlistat vs Xenical: Making the Right Choice
Generic Orlistat vs Branded Xenical: The Facts
Both orlistat 120mg and Xenical 120mg contain identical active ingredients at exactly the same dose. They work by inhibiting lipase enzymes in the gut to block approximately one third of dietary fat absorption. The clinical effect is equivalent — the primary difference lies in cost and manufacturer.
Generic orlistat costs £32.99 for a 4-week supply (£29.69 with EDM10), whilst branded Xenical costs £42.99 (£38.69 with EDM10). Over 12 weeks, choosing generic orlistat can save over £30 compared to Xenical.
Understanding Your Treatment Options
All three options require different approaches. Orlistat 120mg and Xenical 120mg are prescription-only medicines requiring clinical assessment by a UK-licensed prescriber. Both are taken as one capsule three times daily with each main meal containing fat.
Alli 60mg offers half the dose at 60mg per capsule. Available in 4-week supplies from £28.99 (£26.09 with EDM10), Alli provides a lower-strength alternative with typically milder gastrointestinal side effects.
Pricing Comparison: Complete Breakdown
Orlistat 120mg pricing: 2 weeks £16.89 (£15.20 with EDM10), 4 weeks £32.99 (£29.69 with EDM10), 8 weeks £63.99 (£57.59 with EDM10), 12 weeks £95.99 (£86.39 with EDM10).
Xenical 120mg pricing: 2 weeks £21.50 (£19.35 with EDM10), 4 weeks £42.99 (£38.69 with EDM10), 8 weeks £86.99 (£78.29 with EDM10), 12 weeks £128.99 (£116.09 with EDM10).
Which Should You Choose?
Generic orlistat offers identical clinical benefits at lower cost — ideal for budget-conscious patients seeking effective weight management support. Some patients prefer branded Xenical for familiarity with the Roche manufacturer.
Both work best alongside a reduced-calorie, lower-fat diet with no more than 30% daily calories from fat. This minimises gastrointestinal side effects whilst maximising treatment effectiveness.
Online Consultation Process
Complete our online health questionnaire covering medical history, current medications, and BMI information. A UK-licensed prescriber reviews your assessment and issues a prescription where clinically appropriate. Orders are dispensed by our GPhC-registered Leicester pharmacy with next day delivery available.
The online consultation replaces traditional GP appointments, providing faster access to prescription weight loss treatment. All medication is sourced through licensed UK pharmaceutical supply chains meeting MHRA standards.


